The Verde and Black are 1-1-2 in their four games at home while Seattle saw their MLS record-breaking streak of 13 games unbeaten to start a season come to an end with a 1-0 defeat at Minnesota United.
Austin will be without Jon Gallagher as he picked up a left foot injury. Danny Hoesen is sidelined with a hip injury, Nick Lima has a significant hamstring issue, Aaron Schoenfeld had a minor arthroscopic procedure on his left knee with his return date still unknown and Ulises Segura is still out after knee surgery.
The Sounders will still be missing Alex Roldan and Christian Roldan, with El Salvador and the United States respectively for Gold Cup duty. Defender Xavier Arreaga is suspended after picking up his fifth yellow card while Nouhou is out through an adductor strain.
Captain Nicolas Lodeiro is missing with a knee injury with manager Brian Schmetzer unsure when he will return. Will Bruin, Stefan Frei and Shane O'Neill are also out.
Austin FC: Stuver; Jimenez, Cascante, Besler, Kolmanic; Pochettino, Fagundez, Ring; Stroud, Dominguez, Manneh
Seattle Sounders: Cleveland; Smith, Gomez, Cissoko; Medranda, Leyva, Paulo, Atencio, Rowe; Montero, Ruidiaz
Ones to watch
Moussa Djitte could be in line for his Austin debut as the 21-year old was signed by Los Verdes from Ligue 2 outfit Grenoble to provide goals for a side that has only managed ten goals in 13 games.
With Arreaga, Nouhou and O'Neill out, Josh Atencio looks set to start in the midfield. The 19-year old has made seven appearances and four starts for the club after excelling in preseason. Danny Leyva, just 18, has also performed ably in his 336 minutes of action.
The only other matchup between the two teams ended in a 0-0 draw on May 30th in Seattle.
Austin had a chance on 71 minutes as Gallagher pounced on a Seattle turnover and played in Jared Stroud, who was denied by Stefan Cleveland.
The match will be nationally televised by ESPN and ESPN Deportes with kickoff set for 9:30pm Eastern time.