Philadelphia is down to fifth place in the Eastern Conference standings, their lowest point all season, following a 2-1 defeat to Orlando City while the Herons thrashed by New England, their sixth consecutive defeat.
Inter Miami is relatively healthy with only Kelvin Leerman away on international duty and Joevin Jones picking up a knee injury on international duty while with Trinidad and Tobago.
Jamiro Monteiro picked up an ankle injury at the end of the loss to Orlando City, but head coach Jim Curtin said that he will be available for this match. Ilsinho is also back and will see some action while Anthony Fontana passed his concussion test and could feature if he feels no more symptoms.
Inter Miami: McCarthy; Figal, Shawcross, Pirez, Gibbs; Gregore, Matuidi; Morgan, Pizarro, Robinson; G. Higuain
Philadelphia: Freese; Wagner, Elliott, Glesnes, Mbaizo; Bedoya, Flach; Monteiro, Martinez; Santos, Przybylko
Ones to watch
No one is playing well for Inter Miami as evidenced by their two victories on the season but the Higuain brothers are the closest thing the Herons have to playmakers, especially with Rodolfo Pizarro away with the Mexican national team.
Kacper Przybylko and Sergio Santos have proven to be a formidable duo for Philadelphia in recent games with one or the other scoring in three of Philadelphia's last four games.
The Herons have only won twice all season, but one of those was against Philadelphia on April 24th when they came out of Subaru Park with a 2-1 victory.
Gonzalo Higuain and Federico Higuain became the first pair of brothers to score in the same MLS game.
The Union struck first when Kacper Przybylko received the ball in the left side of the penalty area and he found Monteiro, who smashed one in to give Philadelphia a 1-0 lead.
Federico Higuain's free kick found brother Gonzalo, whose header leveled the score in the 73rd minute and he found a winner when he found the back of the net ten minutes later.
The match will be streamed nationally on ESPN+. My33 and CW34 will televise all of the action in Miami while PHL17 will have all of the coverage in Philadelphia. Kick-off is set for 7:30pm Eastern time.