New signings Perry Ng and Max Watters made their debuts last Wednesday night in Cardiff's 1-0 loss at home to Queen's Park Rangers so it is likely that they will both feature again this week.
The Tykes will be looking to rekindle their play-off push after a poor start to 2021, losing all three of their games which all came against promotion contenders.
Valerien Ismael's side are missing four defenders through injury with Ben Williams, Jordan Williams, Aapo Halme and Liam Kitching all unavailable.
Cardiff are without Jordi Osei-Tutu due to a hamstring injury and Lee Tomlin is still sidelined with a groin injury.
Walton; Sollbauer, Helik, Andersen; Brittain, Mowatt, Kane, Styles; Adeboyejo, Woodrow, Chaplin.
Smithies; Ng, Morrison, Nelson, Bennett; Bacuna, Vaulks, Ralls; Wilson, Moore, Ojo.
Barnsley are expected to start with their usual 3-4-3 formation.
Cardiff are under new management but are still likely to use their usual 4-3-3 formation.
Ones to watch
Previously a defensive midfielder, the 20-year-old has adapted fantastically to life as a left wing-back, grabbing two assists, three goals and four Man of the Match awards in the process.
The 24-year-old right-back signed from League One side Crewe Alexandra earlier in the window and impressed on his debut last week against QPR.
Cardiff have won their last five games against Barnsley in the Championship, with their most recent victory over The Tykes coming back in early November in a 3-0 win thanks to goals from Junior Hoilett, Harry Wilson and Joe Ralls.
How to watch
Kick-off is at 7:00pm on Wednesday 27th January and the match is available to watch on both clubs' iFollow streaming service for a fee of £10.