Valerien Ismael's side will be looking for their first win in five after picking up two draws and three defeats in the previous five league outings.
The Rams come into this fixture sitting in 20th position, lurking dangerously close to the relegation places. Despite their poor form, the Tykes are sat in 12th place just six points off of the Championship play-off places.
The home side will be without trio Ben Williams, Liam Kitching and Aapo Halme as they all remain sidelined through injury.
Striker Daryl Dike could be set to make his debut after his loan move from American side Orlando City.
Derby will be without key man Krystian Bielik after manager Rooney confirmed the Polish international tore his ACL for the second time in as many years.
He will be joined on the sideline by defender Curtis Davies who will also miss the remainder of the season due to an achillies problem.
Walton; Brittain, Andersen, Helik, Sollbauer, Styles, Kane, Mowatt, Woodrow, Dike, Chaplin.
Marshall; Byrne, Wisdom, Clarke, Mengi, Buchanan, Bird, Shinnie, Jozwiak, Kazim-Richards, Roberts.
Ones to watch
Cauley Woodrow - Barnsley
Since joining from Fulham in 2019, the 26-year-old has excelled averaging a goal nearly every other game. His all-round forward play is what makes the Luton Town academy product so impressive. This season alone he has scored nine and assisted a further five in just 23 league appearances which is phenomenal for a mid-table Championship side. Under boss Ismael, he has also played in the number 10 role, which also highlights his versatility to play in multiple positions which is a great asset to have for any player.
Patrick Roberts - Derby County
After making his Manchester City debut back in 2015, the 23-year-old has endured a tough few years. Roberts has been out on loan to four different clubs over the last five years, with his most recent being at fellow Championship side Middlesbrough. This loan spell will be crucial in his career, with him getting to the age where he needs to be first-team regular. His speed and dribbling will bring fresh blood into a Derby frontline which has failed to score or create many chances as of late. Could he be the man to lead the Rams to Championship survival?
The two sides last met at Pride Park back in November 2020, with Barnsley running out 2-0 winners thanks to goals from Conor Chaplin and Victor Adeboyejo. Over the last five meetings, it is the Rams who have the better record. They have won on three occasions, drawing one and losing just the once in the previous encounter. In the last meeting at Oakwell, it ended in a 2-2 draw with Woodrow grabbing a 93rd-minute equaliser for the Tykes.
Last time out...
How to watch
Due to the current national lockdown, no fans will be in attendance at Oakwell. This means the game is available on iFollow through Barnsley and Derby's respective club websites, with passes being priced at £10.
The game kicks off at 15:00 BST on Saturday 6 February 2021.