The Bluebirds currently sit six points adrift of sixth placed Bournemouth.
Despite Nathan Jones' Luton being perched in 15th in the Championship, The Hatters still haven't ruled out a play-off push of their own, with them being only three points behind their opposition.
It is expected that Luton will likely field an unchanged starting lineup from last Saturday's narrow win over Birmingham City.
January transfer signing Jonny Williams is in contention to make his debut after picking up a knock in training.
Alex Smithies is still ruled out with illness which will see Dillon Phillips remain in goal.
Sluga, Potts, Bradley, Pearson, Lockyer, Rea, Mpanzu, Dewsbury-Hall, Clark, Cornick, Collins.
Phillips, Ng, Morrison, Nelson, Flint, Bennett, Pack, Vaulks, Wilson, Murphy, Moore.
Since the appointment of the experienced McCarthy as manager, Cardiff's form has altered drastically. The Bluebirds will be coming into the fixture with confidence after comfortably defeating Coventry City 3-1 on Saturday. They have picked up an impressive 11 points from their last five results (winning three and drawing two).
Luton's form has been extremely up and down of recent. Prior to them defeating struggling Birmingham City 1-0 on Saturday, they were without a win in three losing out to Brentford and Blackburn Rovers aswell as picking up a point in their clash with Huddersfield Town.
Ones to watch
Luton Town - James Collins
30-year-old James Collins hasn't been in the form that Luton supporters have come to familiarise themselves with, however, he is still Luton's top goalscorer this season with seven league goals to his name.
The Irishman last found the back of the net in the Hatters' 1-1 stalemate with Huddersfield on 6 February.
Currently Collins is averaging one goal every 289 minutes, which is definitely respectful for a mid-table team like Luton.
But, Cardiff will certainly be aware of the prowess that he possesses with his right boot with five of his seven goals in the Championship this season, coming from his favoured foot.
Cardiff City - Kieffer Moore
Kieffer Moore has seen his name hitting the headlines recently and rightly so.
Since McCarthy took over the reigns at the Cardiff City Stadium from Neil Harris, Moore has been in formidable form netting twice in the 3-1 victory over Coventry on Saturday.
His goal tally is now sitting at 13 goals for the term with the striker backed by many to hit 20 for the season.
The Welsh international's threat is something that Luton will be fully aware of.
The last time Cardiff were defeated by Luton in a league match was way back in October 2005 by a 2-1 scoreline at the Bluebirds' former home Ninian Park.
How to watch
The match gets underway at 20:15 BST at Kenilworth Road on Tuesday, 16 February and will be broadcast live on Sky Sports Football.