Three points are vital for Paul Warne's Rotherham as they look to put some distance between themselves and the relegation zone.
Mick McCarthy will be hoping to build on his side's comfortable win last time out as before Saturday they were without a win in eight games.
Rotherham will be without Chiedozie Ogbene, Joe Mattock and Jamie Lindsay as they are all still recovering from injuries.
The in-form Michael Smith is likely to return up front for the Millers, whilst midfielder Ben Wiles could replace the injured Lindsay.
Goalkeeper Jamal Blackman is still struggling with Covid-19, so Viktor Johanssen will start in between the sticks.
The Bluebirds are missing Jordi Osei-Tutu, Lee Tomlin and Alex Smithies who are all due back later on this month.
Dillon Phillips will replace Smithies in Cardiff City net but apart from that, McCarthy should stick with the same outfielders who started against Bristol City on the weekend.
Johanssen; Ihiekwe, Robertson, MacDonald; Giles, Wiles, Harding, Barlaser, Crooks, Wing; Smith.
Phillips; Morrison, Nelson, Flint; Ng, Ralls, Vaulks, Bennett, Wilson; Moore, Ojo.
Both teams like to operate with a back three, then Rotherham like to have a diamond four in midfield with two wing-backs and a lone striker.
Cardiff on the other hand, use two wing-backs, two holding midfielders, a number ten and two forwards.
Ones to watch
So far this season, Smith has seven goals and two assists in 15 Championship starts.
The six-foot-three striker boasts an intimidating physical presence along with real quality in front of goal.
Smith holds the ball up excellently, he brings others in to play, and has a clinical eye for goal. If he performs, he could be a real handful for the Cardiff City defense.
The Englishman has averaged a goal every 217 minutes this season - the highest rate in the Rotherham squad. He has three goals in his last five games and on his day, he is a defender's nightmare.
Kieffer Moore has had a steady first half of the Championship season, hitting the net 11 times in 23 games.
He is Cardiff's top scorer and the Welsh side have relied on his goals in some important games this campaign.
Moore works tirelessly for the team and he picks up some textbook attacking positions in the final third.
His desire to score goals and composure in front of goal is what makes him a huge danger and if he is not defended properly, he has the ability to punish any team in the league.
He has scored three in his last three games and is currently in some really good form; certainly, one for the Rotherham defense to keep a close eye on.
Out of the last seven meetings between these two sides, Cardiff have won three, Rotherham have won two and there have been two draws.
The last time they played in the Championship was back in 2017.
Cardiff won 5-0 with goals from Kadeem Harris, Junior Hoilett, Graig Noone and Kenneth Zahore sealing an emphatic win for the Bluebirds.
The last time Rotherham beat Cardiff was in 2015 when a last-minute Matthew Connolly own goal gifted them the three points.
Last time out:
Where to watch
This game kicks off at 19:00 BST on Tuesday 9 February 2021.
For Rotherham fans, the game can be watched by purchasing a live video match pass found in the iFollow section of their website.
The same process can be followed for Cardiff fans, found on the Cardiff City TV section of their website.
Both are for a cost of £10.