Their opponents are in similar form in February, with two wins in six.
The Hatters and the Owls are separated by 10 points, however, Wednesday were deducted six points at the start of the season.
Most recently, Luton welcomed Millwall to Kenilworth Road, where the Lions broke the Hatters' hearts by equalising with virtually the last kick of the game.
Elijah Adebayo opened the scoring 10 minutes into the second half. Ryan Tunnicliffe delivered a brilliant cross into the box for Ince to knock the ball on for Adebayo who passed the ball underneath the Millwall 'keeper to put his side ahead.
Millwall centre-back, George Evans, rose highest to a Matt Smith's cross to break Luton hearts in the 95th minute.
On Wednesday night, Sheffield Wednesday were handed a rough 3-0 defeat away to promotion chasers, Brentford.
A long throw into the area allowed Bryan Mbeumo to header home to make it 1-0 in the first half.
The Bees netted their second goal of the evening late into the second half. Mbeumo, this time assisting, teed up Saman Ghoddos to drill home his third goal of the season.
Mads Sørensen secured three points, heading home from Ghoddos’ set-piece to ensure that Thomas Frank’s side were back on the promotion trail.
Midfielder, Eunan O'Kane, remains out with a broken leg.
Tom Lockyer will also miss the clash with an ankle injury.
Sluga; Bree, Cranie, Bradley; Potts, Ruddock, Rea, Dewsbury-Hall; Cornick, Collins; Clark.
Wildsmith; Harris, Lees, Urhoghide, Palmer; Reach, Penney, Hutchinson, Bannan; Paterson, Rhodes.
Ones to watch
The striker is Luton's top goalscorer in the Championship but despite only scoring twice in 2021, Collins is one of the Hatters' biggest attacking threats.
The 30-year-old is a difficult man to get off the ball especially when holding it up.
In terms of attacking threat for Wednesday, they will look to rely on Callum Paterson, who is their top scorer this season so far with seven.
The former Cardiff City striker is a strong player player, who can be a useful asset at both ends of the pitch, a quality that his club will hope he can produce on Saturday.
Sheffield Wednesday 0-1 Luton Town (24/10/2020)
Where to watch
UK residents will be able to watch the game live on their club's individual iFollow on Saturday, 27th February with the game kicking off at 15:00 PM.