The Royals have managed just one win in their last six games, and fell to a forgettable 1-0 defeat against rock-bottom Wycombe Wanderers in midweek.
Veljko Paunovic will be looking for a big response from his team against a struggling Rotherham side, who are winless in four.
The hosts come into the game off the back of four narrow defeats, failing to score in their last three games. Paul Warne's men are currently occupying the final relegation spot; three points against the Berkshire outfit could see them leapfrog Birmingham City, who have played two more games.
Rotherham remain without Jamie Lindsay who was injured in the 2-1 defeat to Preston North End earlier this month. Chiedozie Ogbene and Joe Mattock are also both ruled out for the Millers, with long-term injuries.
Royals playmaker John Swift is still unavailable through injury.
Rotherham: Johansson; Ihiekwe, Robertson, MacDonald, Giles, Olosunde, Barlaser, Wiles, Wing, Crooks, Smith.
Reading: Rafael; Morrison, Moore, McIntyre, Richards, Yiadom, Laurent, Rinomhota, Olise, Joao, Puscas.
Ones to watch
The Millers have struggled defensively this season, shipping 41 goals in 30 games so far. However, Michael Ihiekwe's quality has shone through over the course of the season.
The centre-back has played more minutes for Rotherham than anyone else this term. Ranking as Warne's second top passer, Ihiekwe contributes both offensively and defensively and the 28-year-old will undoubtedly prove to be a threat from set-pieces for the hosts on Saturday.
The Romanian forward has been side-lined with an injury for the majority of the season and when asked if we could see him feature alongside Lucas Joao, Paunovic said:
”Why not? They’ve played like that in the past and also this season when fit so that’s a possibility.”
This weekend could mark George Puscas' long-awaited return to the starting lineup and the former Inter Milan forward will be keen to make an impact.
Rotherham have failed to beat Reading in their last seven attempts, with the Royals reigning successful in a 3-0 win in the reverse fixture earlier this season.
How to watch
The match is available to watch on iFollow through Rotherham or Reading's respective club websites/apps, with match passes available at £10 for those across the United Kingdom.