The Chairboys are 11 points adrift, winning only one game in their last eight as they seek a second season in the second tier for the first time ever.
Garath McCleary and Jordan Obita are set to start against the club that released them last summer, whilst Ryan Allsop is set to miss his second game in a row, with David Stockdale to keep his spot in goal.
Stockdale; Grimmer, Tafazolli, Stewart, Obita, Wheeler, Mehmeti, Knight, McCleary, Onyedinma, Ikpeazu.
Rafael; Yiadom, Morrison, McIntyre, Richards, Laurent, Rinomhota, Esteves, Olise, Ejaria, Joao.
Ones to watch
His sheer brute strength and physicality makes him one of the strongest players in the division, providing a bigh challenge for defenders.
The Portuguese man has been electrifying this season, scoring 17 goals in the Championship. He has struggled with injury in the past hindering his development, but a mostly injury-free season has resulted in brilliant numbers.
The last time these two sides met was earlier in the season when Lucas Joao scored the only goal to separate them in a 1-0 win for the Royals.
How to watch
This match will kick off at 19:45 GMT on Tuesday, February 23, and is available to watch by purchasing an iFollow pass for £10, or on Sky Sports Red Button.