The former Walsall manager took charge of Vale in late February, surprising fans by switching between a divisional rival lower down the table to the Saddlers.
Clarke is yet to dictate his first win for the club, picking up two points from a possible 15 and are looking to avoid their fourth consecutive defeat on Tuesday night.
Oldham aren't in a much better position, sitting in 16th place and having one win in their last six. The club shocked supporters by sacking manager Harry Kewell last night, and whilst antics rise between the fans and the board of the Latics, they expect an immediate turnaround for their troubles.
Clarke will once again be without Christian Montano and James Gibbons due to hamstring injuries, but other than that have a fit squad.
Oldham will be without Zak Dearnley for an extended period of time, after the attacker picked up a knock last week.
Marcus Barnes, Andrea Badan, Cameron Borthwick-Jackson and Sido Jombati will all also be absent.
Kyle Jameson continues his three match ban.
Port Vale: Brown; Mills, Legge, Smith, Crookes, Taylor, Joyce, Conlon, Rodney, Robinson, Hurst.
Oldham Athletic: Lawlor; Fage, Diarra, Piergianni, Adams, McCalmont, Hilssner, Bahamboula, Keillor-Davis, McAleny, Grant.
Ones to watch
Whilst it has not been an admirable season for the Valiants, one man who can hold his head high is 22-year-old Rodney.
The inside forward is a powerful attacker, who uses his brute strength and pace to burst past his man before unleashing a shot. With nine goals and three assists so far this season, he is one of Port Vale's most prized assets right now.
Whilst he didn't start last game due to fitness issues, it hopefully means that he is fit and raring to go for the Latics.
McAleny has been in scintillating form at times this season, netting 12 times from the left wing position, but also being tremendously versatile, appearing in the attacking midfield and sole striker position that Oldham have utilised at times this season.
These two sides last faced one another in late October, but first half goals from Nathan Smith and Mitch Clarke meant that Dearnley's second half strike was meaningless, as Port Vale ran out 2-1 victors away from home.
The match is available on iFollow via Port Vale or Oldham's respective club websites, with match passes at £10 for those in the United Kingdom.