The Canaries currently sit top of the table on 76 points, 10 points clear of second-placed Swansea City.
Meanwhile, the Owls are sat in 23rd place and are seven points from safety with 11 games remaining.
He will join Massimo Luongo, Keiren Westwood, Moses Odubajo and Andre Green on the sidelines with all four of them out through injury.
Daniel Farke may make one change for the trip to Hillsborough with Marco Stiepermann returning this weekend.
The return of the German midfielder means that Sam Byram and Michael McGovern are the only two absentees for the table toppers.
Sheffield Wednesday (4-5-1):
Wildsmith; Urhoghide, Lees, Dunkley, Palmer, Reach, Shaw, Hutchinson, Bannan, Harris, Windass.
Norwich City (4-2-3-1):
Krul; Aarons, Hanley, Gibson, Giannoulis, Skipp, McLean, Buendia, Vrancic, Cantwell, Pukki.
Ones to watch
It is safe to say Adam Reach has not reached the heights of previous campaigns. Over the last few seasons, he has had his own goal of the season competition but this time around, he is yet to produce such moments of magic.
However, he does still have this quality in his locker and can produce it in a blink of an eye. Farke and his Norwich side will need to be wary of this in order to beat Wednesday.
Finland international striker Teemu Pukki has carried on from his last Championship campaign where he bagged a staggering 29 league goals. In his 29 league starts, Pukki has scored 20 goals, making him the club's top scorer once again.
For a spell this season, Pukki was out injured which has prevented him from adding more goals to his already impressive tally. The Owls back four need to prevent him from getting into goalscoring opportunities because more often than not he will find the back of the net.
The last meeting between the sides was back in December, with Norwich running out 2-1 winners thanks to goals from Josh Martin and Max Aarons. The last meeting at Hillsborough ended in a 4-0 win for the Canaries with Pukki, Emi Buendia and Dennis Srbeny on the scoresheet.
Last time out...
How to watch
Due to the current national lockdown, no fans will be in attendance at Hillsborough. This means the game is available on iFollow through Sheffield Wednesday and Norwich's respective club websites, with passes being priced at £10.
The game also live on Sky Sports Football.
The game kicks off at 112:15 BST on Sunday 14 March 2021.