As the Gills miss out on play-offs after recent inconsistent form, they'll be hoping for a strong end to the season to continue into the next campaign.
Meanwhile, the Brewers miraculously survived in the end after Jimmy Floyd Haselbaink was reappointed as manager, for his second spell at the club.
For the hosts, there could be wholesale changes again as Haselbaink will be wanting to experiment with only two left and survival confirmed.
Gillingham could be unchanged from last game out, with pretty much a full squad to choose from ahead of the fixture.
Gerald Sithole may not be available for the visitors, as the youngster picked up a knock in midweek whilst playing for the youth team.
Burton Albion - 4-2-3-1
Garratt; Earl, Brayford, Carter, Hamer; Clare, Taylor; Rowe, Edwards, Powell; Akins.
Gillingham - 4-4-2
Bonham; Jackson, Cundy, Tucker, Ogilvie; Graham, Dempsey, O'Keefe, MacDonald; Akinde, Oliver.
Ones to watch
Josh Earl - Burton Albion
Josh Earl, signed in January for the Brewers, and hasn't featured too much this campaign.
The 22-year-old from Lancashire, on loan from Preston North End, will be hoping he can break into his home town side next season, if Haselbaink opts not to bring him back to The Pirelli.
Vadaine Oliver - Gillingham
Vadaine Oliver is the Gills’ top goalscorer, with 18 goals alongside five assists.
The 29-year-old stands at 6'2 and is a big factor to the southerner's success this season due to his physical presence and goal scoring threat.
He will be hot to handle if the Burton players don't have their weetabix in the morning.
When the sides met back in January, it was Haselbainks first game back for Burton.
The Brewers won 1-0 at Priestfield Stadium, with Hayden Carter scoring his first goal for them.
How to watch
Due to current restrictions in the UK, there will be no fans in attendance at The Pirelli. However, the game is available to watch on iFollow. The kick-off is at 15:00 BST.