The Cottagers sit on 43 points, one ahead of the Cherries with both teams several points clear of third-place Queens Park Rangers in the race for automatic promotion.
Scott Parker will be severely shorthanded for his return to Craven Cottage with Jefferson Lerma suspended as well as Gary Cahill, Lloyd Kelly, Ben Pearson, Adam Smith, Junior Stanislas and Jordan Zemura all out through injury.
Fulham: Rodak; Robinson, Ream, Adarabioyo, Odoi; Reed, Seri; Kebano, Cairney, Wilson; Mitrovic
AFC Bournemouth: Travers; Davis, S. Cook, Mepham, Stacey; Billing, L. Cook, Kilkenny; Anthony, Solanke, Christie
Ones to watch
Aleksandar Mitrovic (Fulham)
He has shown several times in the past that he is the the most lethal scorer in the Football League and is proving that point once again in this campaign, having scored in six consecutive games earlier this season.
The Serb has already bagged an incredible 21 goals from just 19 games and looks to set lead Fulham back to the top flight.
Jaidon Anthony (AFC Bournemouth)
Despite the Cherries throwing away a two-goal lead against Coventry City, the 22-year-old was impressive at wing-back.
Filtering play on the right side was key to Jack Stacey opening the scoring. Bright on the ball, quick on his passes and his non-stop intensity made for a strong performance where he was by far Bournemouth's best player on the day.
It's been two and half years since these sides last met when a 53rd-minute strike by Mitrovic was enough to secure Fulham all three points in a 1-0 victory.
The win was the first in the last four meetings for the Cottagers against the Cherries.
How to watch
The match will be televised on Sky Sports Football with coverage beginning at 19:00 GMT. Kick-off is set for 19:45.