Newport are just one point and one place behind the Cobblers in fifth after their defeat to table-toppers Forest Green Rovers at the weekend.
Defender Aaron McGowan and midfielder Jack Sowerby are doubts for Jon Brady's side following the pair being substituted off in Saturday's win at Walsall.
Forwards Benny Ashley-Seal and Chanka Zimba will definitely not feature as they are sidelined with longer-term injuries.
Northampton Town: Roberts, Harriman, Guthrie, Magloire, Horsfall, Koki, McWilliams, Lewis, Pinnock, Hoskins, Appere.
Newport County: Townsend, Norman, Pask, Demetriou, Haynes, Bennett, Cooper, Cain, Azaz, Baker-Richardson, Telford.
Ones to watch
Striker Louis Appere made the perfect start to his Cobblers career when he scored on his debut against Walsall at the weekend.
The Scottsman got on the end of Mitch Pinnock's free-kick ten minutes into Northampton's win at the weekend, with his goal being the difference between the two sides.
The Englishman has had an excellent campaign for the County this season with 20 goals in 20 games.
The sides have met 93 times previously with Northampton having the upper hand.
The Cobblers have 48 wins, with 15 draws and 30 wins for Newport.
The last time the sides met was in the reverse fixture this season back in September when the Cobblers won by a goal to nil.
How to watch
While the game is not being broadcast live on TV, both sets of supporters can watch the game live via their club iFollow service.