Arsenal manager Mikel Arteta said he is worried about Gabriel Jesus' injury after the Gunners lost 5-3 on penalties to Manchester Untied in the FA Cup after being held to a 1-1 draw in normal time.
Bruno Fernandes fired the holders in front with a swift move followed by a pinpoint finish.
Arsenal centre back Gabriel Magalhaes equalised with a volley after United failed to clear their lines.
Diogo Dalot was sent off just before Arsenal won a controversial penalty, but Martin Odegaard's effort was well-saved by Altay Bayindir.
The Turkish keeper made more important stops as the Gunners faield to convert any of their big chances, as the game went to penalties.
United converted all their penalties with ease, with Arsenal attacker Kai Havertz's miss costing them a place in the fourth round of the cup for the second consecutive season.
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More injuries for Arteta's squad
Along with the disapointment of the result, Arsenal had been dealt with more injury concerns, with four fresh injury problems for Arteta and Arsenal to now deal with.
Before the game, Riccardo Calafiori was not seen with the squad.
When asked this before the game, Arteta said that the Italian defender had suffered a muscle injury, which ruled him out tof the cup tie.
During the game, Dutch defender Jurrien Timber and Jorginho were both subbed in extra time, with both looking like muscle injuries.
Arteta would hope that they are both precautions, with more games coming thick and fast.
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Worrying Jesus injury
Along with these injuries, the most worrying is the injury that Brazilian attacker Gabriel Jesus picked up in the first half.
The Arsenal forward was taken off the pitch on a stretcher in a huge amount of pain, after he suffered two separate incidents on the pitch.
There are huge concerns that he may have picked up an ACL injury, which could see him out for around nine months, a massive blow for both player and club, with Jesus starting to find some form again, and for the Gunners with their lack of attackers becoming a huge concern.
On Jesus' injury, Arteta said: "Big worry. That's my feeling. He had to come off on a stretcher with a lot of pain. Touching his knee, it’s not looking good."
When asked whether the injury was similar to the one he suffered at the 2022 World Cup, Arteta said: "No, I think it's the other one. The worrying factor is the feeling that he had. He had to come off and the pain that he was in."
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Injury concerns ahead of North London Derby
This Wednesday, the Gunners are back at the Emirates as they face arch-rivals Tottenham, who also had to play 120 minutes in the cup yesterday as they beat non-league side Tamworth 3-0 after being held to a goalless draw in normal time.
Ahead of the game, it is uncertain who will be fit for Arsenal, with the injuries and fatigue picked up in the United game looking costly to the squad and their chacnes in this fixture.
This will hurt Arsenal more than other teams, with the Gunners boasting the joint smallest sqaud size in the league, with only 24 players available for Arteta to choose from.
Despite all of this, Arteta is still looking forward to the fixture on Wednesday, as he said: " Regardless of if we would’ve won the last two games, it's exciting and looking forward to play the biggest game of the season for our supporters and what it means to us."
