The hosts are currently only a single point away from the relegation playoff place, which is currently occupied by Wehen Wiesbaden, and two points from relegation spots.
Although Regensburg sit higher in the table than their opposition, they are also only five points way from the relegation playoff spot, with the game set to be a crucial six-pointer for both sides in what is an incredibly tight league at the bottom.
The home side suffered a 3-1 defeat away to Erzgebirge Aue last weekend and had a man sent off. Regensburg did better, an Andreas Albers penalty in the second minute of extra time to claw them back to a draw against Holstein Kiel.
Sandhausen will be without Dennis Diekmeier and Kevin Behrens for Saturday's game, who both are suspended due to picking up red cards. Behrens will be a big miss for the home side who will not have their star striker. Erik Zenga and Markus Karl both have ACL injuries and will also be unavailable.
For Regensburg, Sebastian Nachreiner and Benedikt Saller are both suspended and will not be able to play.
Sandhausen: Fraisl; Klingmann, Nauber, Zhirov, Paqarada; Scheu, Taffertshofer, Paurevic, Linsmayer, Baida; Aziz Bouhaddouz
Regensburg: Meyer; Hein, Nachreiner, Correia, Okoroji; Stolze, Gimber, Besuschkow, Wekesser; Gruttner, Makridis
Ones to watch
Aziz Bouhaddouz will be SV Sandhousen's main man in front of goal and the most likely way that they will score. He is their second highest scorer this season with six goals, although far behind Kevin Behrens, and started up top in their 3-1 defeat against.
Marco Grüttner, who started for Regensburg against Holstein Kiel, will be their main threat on Saturday if he starts, alongside Andreas Albers who appeared as a substitute last weekend. Both have scored seven goals this season and are their team's main outlet going forwards.
SV Sandhausen 0-1 Jahn Regensburg
Both sides have struggled this season, but Regensburg may fair better than Sandhausen in Saturday's match.
Jahn Regensburg earned themselves a point last weekend against Holstein Kiel, coming back from two behind, and will look to improve on that in this weekend's game.
Sandhausen have had a much worse run of form, struggling without Behrens up top in their previous game. They are now winless in their last seven and without a win in their last five home games, something which Regensburg will look to take advantage of.