Hosts Dortmund are currently four points adrift in second place after 27 matches but are just three points ahead of third place RB Leipzig.
Both sides have two wins from two since the Bundesliga returned from its suspension on the 16th of May.
BVB won this fixture last season, coming out 3-2 winners at the Westfalenstadion.
They were humbled in the reverse back in November, however, with Bayern dispatching them 4-0.
In addition, ex-Bayern defender Mats Hummels is a doubt after limping off at half time in the 2-0 win over Wolfsburg at the weekend.
As for the visitors, Phillippe Coutinho, Niklas Sule and Corentin Tolisso will all miss out, whilst Thiago will face a late fitness test to prove his availability.
Borussia Dortmund (3-4-2-1) Burki - Piszczek, Hummels, Akanji - Hakimi, Dahoud, Can, Guerreiro - Brandt, Sancho - Haaland
Bayern Munich (4-1-4-1) Neuer - Pavard, Alaba, Boateng, Davies - Kimmich - Coman, Muller, Goretzka, Perisic - Lewandowski
Erling Haaland vs Jerome Boateng
Norwegian wonderkid Erling Haaland may have failed to find the net at the weekend, but the teenager has been a revelation this season having moved to the Black and Yellow in January.
Jadon Sancho vs Alphonso Davies
English winger Jadon Sancho has been used fleetingly by Favre since football returned in Germany but he put in a fine cameo off the bench at the weekend, assisting the second goal.
On Tuesday night he will come up against Bayern's breakthrough star this season, Canadian Alphonso Davies who has been adjusted from a left winger ton a left back since arriving from Vancouver Whitecaps, with stunning results.
What they have said
Lucien Favre, Borussia Dortmund manager: “Compared to the first leg, we have a different formation that fits our squad better. We also have Emre Can and Erling Haaland, two strong players who’ve increased the quality of our team.”
Hansi Flick, Bayern Munich manager: "BVB have found a lot of defensive stability after changing their formation. I imagine they will start quite defensively. But if they try something else, we'll definitely be ready."