The Wolves welcome Dortmund off the back of a stoppage-time win over Augsburg last weekend, Daniel Ginczek's goal sealing a 2-1 win.
The hosts are in sixth at present, two points ahead of seventh but 11 adrift of fifth placed Bayer Leverkusen.
In addition, they won the reverse fixture at Signal-Iduna Park 3-0 back in November.
As for the visitors, Dan-Axel Zagadou (knee) and Axel Witsel (muscular problems) remain sidelined and Marco Reus is lacking match fitness.
However, Emre Can and Giovanni Reyna are both available after sitting out the Revierderby last weekend.
VfL Wolfsburg (3-4-2-1) Casteels - Knoche, Pongracic, Brooks - Mbabu, Guilavogui, Arnold, Roussillon - Mehmedi, Brekalo - Weghorst
Borussia Dortmund (4-2-3-1) Burki - Piszczek, Akanji, Hummels, Guerreiro - Dahoud, Delaney - Sancho, Brandt, Hazard - Haaland
Wolfsburg centre backs vs Erling Haaland
Norwegian striker Erling Haaland has been a revelation this season, having scored 28 goals for Red Bull Salzburg prior to arriving in Germany in January.
Since his move to Dortmund, the 19-year-old has bagged 13 goals in just 12 goals, with three assists too.
Thus, the Wolfsburg defence will be hard-pressed to stop the 'Man Child' from finding the net once more this weekend.
Kevin Mbabu vs Raphael Guerreiro
Former Newcastle United full-back Kevin Mbabu will have to make use of his defensive capabilities from right wing-back on Saturday when he faces Raphael Guerreiro.
Dortmund's Portuguese left-back was in impressive attacking form last time out as he scored twice in the defeat of rivals Schalke.
The former Lorient man now has ten goal contributions in the league this season from defence.
What the managers have said
Oliver Glasner, VfL Wolfsburg manager: "Dortmund are in very good form and they've become deadlier and defensively stronger since the change of system. They're hard to play against, but of course we want to win and will give our best."
Lucien Favre, Borussia Dortmund manager: “Wolfsburg has changed a few things tactically. They have a more concrete first team and are very stable.”