49ers vs Cowboys LIVE, Score Updates and Play-by-Play in NFL

Consistency separates 7-1 from 4-5 over the past month.

Dallas has alternated results since Week 5: losing 24-16 vs Tampa Bay on Oct. 8 and 23-13 at Green Bay on Oct. 18, routing division rival Philadelphia 38-21 on Oct. 26, dropping that 33-30 overtime shootout to Arizona on Nov. 1, and rallying 27-23 at Indianapolis last Sunday behind Ryan Flournoy (53 yards on two catches) and Lamb's 195 yards.

San Francisco has won four of its past five games: beating Denver 24-14 on Oct. 4, edging Seattle 32-29 on the road on Oct. 11, topping Washington 23-17 on Oct. 19 and blowing out Las Vegas 38-17 last Sunday around a lone 29-20 road loss at Atlanta on Oct. 25.

Points fly whenever two top-five scoring offenses meet on fast indoor turf in Arlington.

DraftKings installs 7-1 San Francisco as a 4.5-point road favorite (SF -4.5, moneyline -218; Dallas +180) alongside a towering 55.5-point over/under total, the highest number on the Week 10 slate. Combined, these offenses average 56.7 points and 750.9 total yards per game (382.8 for San Francisco, 368.1 for Dallas).

ESPN's Matchup Predictor projects a 63.8 percent win probability for San Francisco against 35.9 percent for Dallas (0.3 percent tie), while outside temperatures sit at a brisk 49 degrees with 20 mph gusts across Tarrant County outside the retractable roof.

Check both four-team division tables entering 4:25 p.m. ET:

NFC West: San Francisco 49ers 7-1 (.875, +79 point differential at 235 scored and 156 allowed), Seattle Seahawks 5-4 (.556, 202-162), Los Angeles Rams 5-4 (.556, 214-181), Arizona Cardinals 3-6 (.333, 178-255).

NFC East: New York Giants 5-3-1 (.611, 203-196), Dallas Cowboys 4-5 (.444, +10 differential at 246-236), Washington Commanders 3-5-1 (.389, 196-223), Philadelphia Eagles 2-7 (.222, 148-221).

Dallas owns just one win in four tries inside AT&T Stadium this autumn (1-3 home, 3-2 road) after dropping home dates to Tampa Bay (24-16 on Oct. 8) and Arizona (33-30 in overtime on Nov. 1).

Nine rushing touchdowns in nine weeks tell you how Dallas finishes red-zone drives.

Losing Tyler Goodson to Injured Reserve leaves tailback Javonte Williams handling the vast majority of early-down and goal-line work behind guards Tyler Smith and rookie Tyler Booker, center Cooper Beebe and tackles Tyler Guyton and Terence Steele, with fullback Hunter Luepke and reserve Israel Abanikanda mixing in on passing downs.

Williams has racked up 154 carries for 629 rushing yards (4.08 average) and nine touchdowns in 2026, punctuated by 20 carries for 101 yards and a score plus four receptions for 23 yards at Indianapolis last Sunday. Cracking Fred Warner and San Francisco's 80.9-yard run wall determines whether Dallas stays balanced at 103.6 rushing yards per game or asks Dak Prescott to drop back 42 times against Nick Bosa.

Sixty-six rushing yards per game separate these two run defenses.

San Francisco surrenders an NFL-stingy 80.9 rushing yards, 222.9 passing yards and 19.5 points per game (303.8 total yards allowed) behind All-Pro middle linebacker Fred Warner (77 total tackles) and edge rusher Keion White (3.5 sacks), joined up front by perennial Pro Bowlers Nick Bosa and DeForest Buckner.

Conversely, Dallas yields 147.4 rushing yards, 26.2 points and 384.4 total yards per game, forcing rookie safety Caleb Downs (team-leading 55 tackles) and safety Markquese Bell to clean up far too many open-field runs in the second level. When Christian McCaffrey, fullback Kyle Juszczyk and rookie back Kaelon Black (11 carries, 70 yards vs Las Vegas) stay in second-and-short, Brock Purdy punishes linebackers on play-action crossers over the middle.

Every press-box binocular in Arlington points straight at left tackle Trent Williams and Dallas's cornerback group.

San Francisco lists All-Pro blindside protector Trent Williams as questionable alongside starting cornerback Renardo Green (questionable), while defensive tackles C.J. West and Gracen Halton plus cornerback Nate Hobbs remain on Injured Reserve. Whenever Williams misses snaps or plays at less than 100 percent, backup tackles Vederian Lowe and Colton McKivitz draw tall pass-rush assignments against Dallas interior wreckers Quinnen Williams (team-high 5.0 sacks) and veteran Kenny Clark.

Dallas rules out rookie linebacker Donovan Ezeiruaku and placed backup running back Tyler Goodson (77 yards on 12 carries at 6.4 yards per rush last Sunday in Indianapolis) on Injured Reserve. Starting cornerbacks DaRon Bland and Joey Porter Jr. plus defensive tackle Jonathan Bullard carry questionable tags for a Cowboys secondary already surrendering 237.0 passing yards per outing alongside veteran corner Cobie Durant.

San Francisco has lost once since Labor Day.

Quarterback Brock Purdy has connected on 163 of 236 throws (69.1 percent) for 1,980 yards, 17 touchdowns and five interceptions while adding scrambling punch like last Sunday's seven carries for 40 yards and a rushing score against the Raiders. Running back Christian McCaffrey already owns nine rushing touchdowns on 102 carries (457 yards) and caught another touchdown pass last weekend, giving Shanahan's offense 29.4 points and 382.8 total yards per game (247.5 passing, 135.3 rushing).

Tight end George Kittle leads all 49ers pass-catchers with 38 receptions for 483 yards and five touchdowns, complemented by rookie Jordan Watkins (four grabs, 86 yards and a touchdown vs Las Vegas) and veteran Brandin Cooks.

Dallas still throws the football as explosively as anybody in the NFC.

Quarterback Dak Prescott enters Week 10 completing 218 of 336 passes (64.9 percent) for 2,381 yards, 16 touchdowns and five interceptions, piloting an offense that generates 27.3 points and 264.6 passing yards per game. Seven days ago in Indianapolis, Prescott carved up the Colts on 21-of-34 passing for 335 yards, two touchdowns, zero interceptions and a 114.2 passer rating.

All-Pro wideout CeeDee Lamb hauled in 10 of 16 targets for 195 yards and a score in that win, pushing his nine-game season line to 70 receptions, 904 yards and seven touchdowns alongside boundary threat George Pickens (39 catches, 533 yards, 13.7 average, two touchdowns) and tight end Jake Ferguson.

Welcome to Arlington and VAVEL's live press-box coverage of San Francisco 49ers at Dallas Cowboys in the national NFL Week 10 late window on FOX. Kickoff inside AT&T Stadium is scheduled for 4:25 p.m. ET (3:25 p.m. local CST).

Classic NFC heavyweights, starkly different records.

Kyle Shanahan's San Francisco 49ers arrive atop the NFC West at 7-1 (.875, 2-1 road, 4-1 conference) after routing Las Vegas 38-17 last Sunday. Brian Schottenheimer's Dallas Cowboys sit 4-5 overall (1-3 at home, second in the NFC East) fresh off a 27-23 road victory at Indianapolis on Nov. 8.