A win for Brentford will see them leapfrog Swansea City and enter the top two of the Championship. Bristol City dropped to ninth this weekend and will be hoping to close the gap on sixth-placed Bournemouth with a win.
Charlie Goode could return on Wednesday after missing the game at the weekend through illness. Winger Brian Mbuemo sat out of the victory against the Chairboys but could make a return in midweek.
Midfielders Christian Nordgaard, Emiliano Marcondes and Shandon Baptiste will all out sit out of the midweek fixture after the trio remained sidelined through injury.
Swedish defender Pontus Jansson will also be out after struggling with an ankle problem.
Bristol City have six players sidelined through injury ahead of the game on Wednesday. Andreas Weimann, Steven Sessegnon, Jay Dasilva and Callum O'Dowda have all been struggling and won't feature for the Robins.
Wing back Tommy Rowe was taken off after 34 minutes through injury at weekend and looks unlikely to feature for Dean Holden's side.
Raya; Dalsgaard, Sorensen, Pinnock, Henry, Jensen, Dasilva, Ghoddos, Fosu, Toney, Canos.
Bristol City (4-4-2):
Bentley; Hunt, Kalas, Mawson, Mariappa, Palmer, Nagy, Massengo, Semenyo, Wells, Diedhiou.
Ones to watch
Ivan Toney - Brentford
Since signing from Peterborough United for a reported £10 million, Toney has made his mark on the division. Despite having a mini seven-game goal drought, the 24-year-old striker grabbed a double at the weekend taking his tally to 18 league goals in his first 25 appearances. The Newcastle United academy product has shown great maturity levels and composure in front of goal and proved to be worth every penny. If he keeps up his goalscoring record, it won't be long before he follows in ex Brentford striker Ollie Watkins footsteps and secure a big-money move to the Premier League.
Nakhi Wells - Bristol City
The Bermuda international has enjoyed a good start to life in Bristol. He has formed a good partnership with fellow striker Famara Diedhiou with the pair grabbing 13 league goals between them. Wells has always been known for his speed and agility in the final third. This year has been no different. One disappointment the former Burnley man will have, is that he he has not grabbed more goals. He has a respectable tally of five league goals but will have hoped for more. The striker will be hoping to add to his tally against Bristol City on Wednesday.
The two sides last met back in January 2020, with Brentford running out 4-0 winners at Ashton Gate thanks to goals from Mbuemo, Said Benrahma and Watkins. Over the last five meetings, both sides have won just the once and there have been three draws. The last meeting at home for Brentford ended in a 1-1 draw at Griffin Park.
Last time out...
How to watch
Due to the current national lockdown, no fans will be in attendance at the Brentford Community Stadium. This means the game is available on iFollow through Brentford and Bristol City's respective club websites, with passes being priced at £10. The game is also available on Sky Sports Football.
The game kicks off at 19:45 BST on Wednesday 3 February 2021.