The visitors returned back to South London with only their second win on Tyneside in the Premier League era, gaining revenge for the 2-0 defeat suffered to the Magpies at Selhurst Park back in November.
But this was concerning for Newcastle who have now lost their sixth home league game in the 2020/21 season, more home defeats than they suffered in the entirety of the 2019/20 campaign.
A bright start but not enough
Captain for the night Jonjo Shelvey got his side off to a flyer, scoring within 70 seconds of the kick-off as the Magpies started the game on the front foot.
After a short flurry of chances in the first 10/15 minutes, Newcastle struggled to find their rhythm again but they were looking comfortable until Jairo Riedewald's powerful deflected effort got Palace level with 21 minutes played.
Gary Cahill's header turned things around just four minutes later as he headed home from a right-wing free-kick, and barring Andros Townsend's late sitter that he missed, Palace created very little else throughout the 90 minutes.
Newcastle did dominate possession but were unable to create any clear cut chances as the game wore in with their opponents forcing them to take long shots, most of which went high over the crossbar.
More possession but still no difference
Recent matches between Newcastle United and Crystal Palace have tended to be tight and often uneventful ties as both teams' try to play the same way, on the counter-attack.
This encounter was more exciting for the neutral but it turned out to be the counter-attackers on the night who came out on top with the Magpies having 61% of the ball, a figure that is unheard of in recent years at St James' Park, or at least from a Newcastle point of view.
The downside to having this amount of the ball is the fact that Newcastle didn't really do anything with their dominance on the ball and were often made to pass around the back, something which suited Palace.
No Newcastle players were really willing to take those risks to get the ball forwards and the majority of attacks broke down.
Roy Hodgson's sides are always difficult to face and this was no exception on Tuesday evening as Palace put in the perfect away performance.
The Eagles had struggled for form in recent matches, up until their 1-0 win over Wolverhampton Wanderers at the weekend and they built on this with their latest three points against Newcastle.
Newcastle are used to being the side who go to away grounds with the aim of sitting deep and catching opposing teams out, but they were on the other end for a change.
It appears that Newcastle don't really have the key to unlock a side who sit deep, especially when they are as organised and as disciplined as Hodgson's side.
The Saints are certainly no strangers to a defeat like this though, with them being on the wrong end of the same scoreline against Leicester City, just last season.
Manager Ralph Hasenhüttl could easily have walked after that embarrassment but he stuck with the Saints and they certainly turned their fortunes around.
Southampton responded to that loss and they will be hoping to do the same again on Saturday afternoon at St James' Park. Newcastle will be doing all they can to ensure they don't gift their opponents three points.