Ian Evatt has masterminded a tremendous turnaround in Bolton's fortunes, as their early season woes have faded with the club climbing into the play-off places following a tremendous six game winning streak.
Their winning run was put to an end on Saturday, but Bolton will be vying to go again after a stoppage time strike from Bradford City clinched a point.
The visitors, Cambridge, have been inconsistent recently and in patchy form, with just four wins in their last eight and currently struggling to pick up back-to-back victories.
Mark Bonner's U's currently sit in second place and just one point adrift of Cheltenham Town, but have a difficult run of games with Bolton, Forest Green Rovers, Morecambe, Tranmere Rovers and Exeter City coming up in the next few weeks.
Evatt will once again be without Liam Edwards and Dennis Politic.
Bonner will be without Paul Digby, who is still battling for fitness.
Bolton Wanderers: Gilks; Jones, Santos, Baptiste, John, Lee, Williams, Isgrove, Sarcevic, Afolayan, Doyle.
Cambridge United: Burton; Knoyle, Drysdale, Taylor, Dunk, May, O'Neil, Boateng, Hoolahan, Mullin, Ironside.
Ones to watch
An absolute man mountain at the back, Santos is enjoying his first year with the Trotters.
The Portugese defender is a wall at the back and has even been described by some Bolton fans as the best centre-back in the league. Having made 33 appearances this season, Santos is one of the most consistent players in the league right now, and will be tested on Tuesday against the league's top scorer, Paul Mullin.
As stated before, Mullin is the league's top scorer with 23 goals and a constant headache for opposition defenders.
His darting pace and blistering shot frightens any opposition, but with his excellent movement he avoids being man marked and constantly wants the ball. With an average match rating of 7.02, he has been a key component behind Cambridge's title charge.
These two sides have actually only ever faced one another once before, which came earlier in the season. It was a stalemate however, as an own goal from Billy Crellin was cancelled out by a late Antoni Sarcevic goal back in October.
The match is available on iFollow via Bolton or Cambridge's respective club websites, with match passes at £10 for those in the United Kingdom.