The visitors come into the game on the back of a 3-2 win away at Bournemouth at the Vitality Stadium on Saturday which further cemented their place in the play-offs with ten games to go.
The Chairboys come into the game on the back of a 1-0 home victory against Preston North End on Saturday. Ryan Tafazolli's first half header sealed the win for Wycombe.
Barnsley boss Valerian Ismael will still be without Ben Williams as he hasn't featured since his injury ruled him out. Other than that Barnsley will have a full squad to choose from.
Wycombe Wanderers (4-2-3-1)
Stockdale, McCarthy, Knight, Tafazolli, Jacobson, Gape, Thompson, McCleary, Mehmeti, Horgan, Ikpeazu.
Collins, Sibbick, Helik, Andersen, Brittain, Mowatt, Palmer, Styles, Frieser, Woodrow, Morris.
Ones to watch
Anis Mehmeti broke into the Wycombe side this season and the 20-year-old has featured 21 times and has scored two goals. His quick feet and turn of pace is something Barnsley will have to watch out for when the two sides meet.
Since signing from Norwich City in January, Carlton Morris has been in fine form for Barnsley. He has scored five goals in 13 appearances and has provided two assists and Wycombe's defence will be have to be on top form to stop him.
When the two sides last met it was Barnsley who triumphed as they ran out 2-1 winners at Oakwell. In the last five meetings Barnsley edge it winning three, with one draw and Wycombe winning the other.
How to watch
Due to the current national lockdown, there will be no fans in attendance when the two sides meet at Adams Park. This means the game will be available on iFollow through Wycombe's and Barnsley's respective club websites, with passes priced at £10.
The game kicks off at 19:00 GMT on Wednesday 17 March 2021.