Brentford will be looking to make amends for their game against Derby County in midweek after throwing away a two-goal lead to draw 2-2.
Nottingham Forest will also look to stop their poor run of form that has seen fail to pick up three points since a 1-0 win away at Rotherham United almost a month ago.
Coming into the game, the Bees are sat in fourth place, five points off second place Watford, but do have a game in hand.
Meanwhile, the Reds are sat in 18th place with a nine-point cushion to the drop zone with nine games left to play.
Pontus Jansson returned to action on Tuesday night and looks set to keep his place alongside Winston Reid at the back.
Rico Henry remains sidelined with a hamstring strain with Mads Beck Sorensen set to continue at left full-back.
Thomas Frank will also be without Josh Dasilva and Shandon Baptiste with injuries ruling the pair out once again.
Forest will be without winger Joe Lolley, who has a hamstring injury that will see him miss the remainder of the season.
Joe Worrall will once again be absent after picking up a rib injury against Watford.
Goalkeeper Brice Samba and winger Anthony Knockaert will face late fitness tests to see if they can take any part in the game.
Despite returning to training, Harry Arter will miss the game in London.
Brentford (4-3-3): Raya; Dalsgaard, Jansson, Reid, Sorensen; Jensen, Janelt, Ghoddos; Canos, Mbuemo, Toney.
Nottingham Forest (4-2-3-1): Smith; Christie, Figueiredo, McKenna, Ribeiro; Garner, Yates; Ameobi, Cafu, Mighten; Murray.
Ones to watch
Ivan Toney - Brentford
Eyebrows were raised when Brentford forked out a club record £10 million fee for Peterborough United striker Ivan Toney, but it is safe to say the 24-year-old has certainly justified that price tag. Toney was always going to have big boots to fill after Ollie Watkins left to join Aston Villa, but no one could have predicted his start to life in the Championship. The striker has bagged 27 goals and nine assists from his first 36 Championship games, picking up nine man of the match awards in the process.
It is certainly early days for Toney, but if he keeps up this goal scoring record he is destined for a big-money move in the summer.
Scott McKenna - Nottingham Forest
The Scottish international centre back has a decent first season in English football despite the Reds' league position. Joining from Aberdeen in the summer, he immediately impressed with his ability in the air and quality on the ball. Forest were crying out a left-footed central defender all of last season and it is safe to say McKenna has filled the void.
He has been unlucky with injuries this season but now he is back in the squad and even taking the armband, he could be the man to keep the in-form Toney quiet on Saturday.
The last meeting between the sides came back in December with the Bees taking all three points at the City Ground in a 3-1 win with goals coming from Henrik Dalsgaard, Toney and Dasilva.
Forest are yet to play at the Brentford Community Stadium and their previous visit on Brentford soil came at Griffin Park back in January last year with the Reds winning 1-0 thanks to Joe Lolley.
Last time out...
How to watch
Due to the current national lockdown, no fans will be in attendance at the Brentford Community Stadium. This means the game is available on iFollow through Brentford and Forest's respective club websites, with passes being priced at £10.
The game is also available on Sky Sports Main Event, with a 12.30pm kick-off on Saturday.