There are differing expectations for both clubs this season. Derby's struggle to recruit players sees them tipped for another relegation battle, while the Ammies are among the favourites for promotion to League One.
Despite being two divisions apart, this will be their second meeting in under a month. Salford won 2-1 when they met in July in a pre-season friendly at the Pennisula Stadium.
Rams boss Wayne Rooney will hand starts to goalkeeper Ryan Allsop and midfielder Ravel Morrison in this tie.
Allsop joined the club on Friday and made the bench against Huddersfield, while Morrison was announced close to kick-off and therefore unavailable.
Striker Jack Stretton will return to the squad following a muscle strain, while defender Lee Buchanan remains out with a thigh injury.
Captain Tom Lawrence is available after sustaining an eye injury on Saturday.
Allsop; Ebosele, Stearman, Davies, Williams; Bird, Shinnie; Sibley, Lawrence, Morrison; Kazim-Richards.
King; Shephard, Lowe, Turnbull, Touray; Lund, Willock; Thomas-Asante, Morris, McAleny; Elliott.
Ones to watch
Ravel Morrison - Derby
The signing of Morrison was announced inside Pride Park on Saturday to the delight of the home crowd. The 28-year-old penned a one-year deal and will hope for a better run of games than he had at his previous clubs. While his career to date has not lived up to expectations, there is no doubting the quality he possesses, which was evident while on trial with the Rams. Rooney must now get him performing consistently.
Matty Lund - Salford
Lund scored 11 goals and provided five assists last season in League One for Rochdale, but they could not avoid relegation. He signed a one-year deal with the Ammies after turning down an offer to stay at Dale. Considering he's capable of performing in the division above, it's a real coup for Bowyer's men.
The 2-1 victory for Salford last month is the only other time these sides have met. They went 2-0 ahead through a Josh Morris penalty and Tom Elliott header before Jordan Turnbull scored an own goal.
How to watch
If you're unable to be at Pride Park, the game will be available to watch on Sky Sports Football. Coverage starts at 19:30 BST with kick-off at 19:45 BST.
What the managers have said
On team selection: “I will play a strong team, but there will be a few changes.
“I never like doing too many as I want this club to go on a good cup run, but I think it would be good for everyone.
“I am confident in the team that will start and I am confident that that team can go out there and win the game.
“We will be ready. I believe we will have enough to go out and get the victory we want.”
On Salford: “We played Salford in pre-season, but at that stage it was about fitness and preparing for the season.
“We know what Salford will be about and they are a difficult team to play against.
“They are physical and get the ball forward, but they also try and play. We are well prepared and ready to get out here.”