The Bees have taken five points from their first three games as members of the Premier League while the Seagulls collected six points from their first month of fixtures.
Frank Onyeka returned to training following a spell on the sidelines as the midfielder battled COVID-19 and he is set to reclaim his spot in the starting lineup.
The Bees will continue to be without Mads Bech Sorensen (knee) and Josh Dasilva (hip). Defender Mathias Jorgensen was signed on a one-year deal, but may not feature as he waits for his work permit and international clearance.
Brighton will welcome Solly March back into the squad as the midfielder has recovered from a hamstring issue that forced him to miss the club's last match against Everton.
Aaron Connolly trained lightly on Thursday as he deals with a minor glute injury and manager Graham Potter is hopeful he will be in the squad.
Marc Cucurella, signed during the transfer window from La Liga club Getafe, is available for selection while Jurgen Locadia is in contention to be included following the end of his loan spell with FC Cincinnati.
Tariq Lamptey will miss out as he deals with a hamstring injury and defender Dan Burn is also sidelined as he continues to nurse a knee issue.
Brentford: Raya; Ajer, Jansson, Pinnock; Canós, Onyeka, Nørgaard, Janelt, Henry; Toney, Mbeumo
Brighton & Hove Albion: Sánchez; Dunk, Duffy, Webster; Cucurella, Bissouma, Lallana, Groß; Mac Allister, Trossard; Maupay
Ones to watch
Ivan Toney opened his top-flight account in Brentford's last match against Aston Villa as he looks to replicate the form that saw him win the Golden Boot award as the top scorer in the EFL Championship with 31 goals.
Former Bees striker Neal Maupay will be Brighton's main goal-scoring threat. The Frenchman scored 41 times for Brentford before moving to the South Coast for around £20m in 2019, where he has since found the net 20 times under Potter's management.
This is the first matchup between the two sides since February of 2017 when the match ended in a 3-3 draw at Griffin Park.
Brentford were in control having scored twice in the opening 22 minutes through Jota and Harlee Dean and they had the opportunity to extend their lead but David Stockdale denied Lasse Vibe from the penalty spot.
March fired home emphatically from the edge of the box with 15 minutes to go to cut the Bees lead in half before Shane Duffy nodded in a cross from Anthony Knockaert to level.
Konstantin Kirschbaumer appeared to have nicked a winner in the fourth minute of second-half stoppage time for the hosts, but Tomer a bullet header by Tomer Hemed ensured a share of the spoils.
How to watch
With no live coverage in the UK, the only way to follow the action is through BeesPlayer for Brentford and MyAlbion TV for Brighton. Kick-off is set for 3pm UK time.