The Black Cats are ten games unbeaten under the guidance of manager Alex Neil, who took over in February and victory could see the Wearsiders clinch at least a play-off place.
Rotherham could go joint top of the table with a win of their own and a defeat for Wigan as the Millers seek an immediate return to the Championship.
Lyndon Gooch and Danny Batth will retain their places in the starting lineup following impressive performances in the victory over Cambridge.
Carl Winchester was withdrawn early on Saturday and will miss out here. Dennis Cirkin is doubtful after missing the match against the U's.
Starting goalkeeper Lee Burge played the full 90 minutes in a U-23 game, but it's expected Anthony Patterson will remain in goal.
Shane Ferguson's season has come to an end due to a foot injury while Will Grigg remains sidelined with a hamstring injury and would be ineligible against his parent club regardless.
Ones to watch
Nathan Broadhead (Sunderland)
The Welshman has been in fine form recently, scoring four goals in the Black Cats' last five matches and he will again lead the attack alongside the impressive Ross Stewart.
Michael Smith (Rotherham United)
He's the Millers' leading scorer with 18 goals, good for sixth in the league and recently netted the match-winner against Ipswich to keep his side on track for promotion.
Sunderland: Patterson; Doyle, Wright, Batth; Roberts, Embelton, Evans, O'Nien, Gooch; Broadhead, Stewart
Rotherham United: Johansson; Edmonds-Green, Wood, Ihiekwe; Osei-Tutu, Barlaser, Rathbone, Wiles, Harding; Ogbene, Ladapo
Rotherham ran away with a 5-1 victory in the reverse fixture last October with Sunderland finishing the match with ten men.
Four minutes from halftime, Smith turned provider as he sent a low cross in that Ladapo finished from close range.
The lead was doubled in the 53rd minute with Ferguson's corner powered home by Carl Ihiekwe.
Aiden McGeady was sent off for a late, lunging challenge on Wes Harding and Smith's header from the back post made it 4-1.
Rotherham finished off the rout two minutes from time when Joshua Kayode rounded Ron-Thorben Hoffmann and passed to Ladapo, who tapped home.
There will be no live streaming or broadcast coverage of the match. The only way to tune in is to listen to live commentary on BBC Newcastle.
Kick-off is set for 14:45 GMT.