Goals from Thomas Soucek and Jarrod Bowen ensured Manchester United had a miserable return to Premier League action.
The visitors put an end to their poor league form with a 2-0 win at Old Trafford, which has left Ruben Amorim's side in 16th position, while the Hammers now sit in 15th.
Amorim rotated the side that beat Athletic Bilbao comfortably on Thursday night, but key players such as Bruno Fernandes, Leny Yoro and Noussair Mazraoui remained in the starting lineup, while Mason Mountwas handed a start after his midweek brace.
United began the game brightly and almost took the lead through Amad Diallo, however Alphonse Areola made a smart save to deny the winger.
West Ham threatened to take the lead early on through Max Kilman, but it was Soucek who opened the scoring from close-range, after some terrific footwork from Mohammed Kudus.
The Red Devils were unable to find a equaliser and instead Bowen doubled West Ham's advantage to secure their first win at Old Trafford in 18 years.
Here are the key takeaways from the contest.
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Leny Yoro injury scare
The biggest concern for Amorim won't be the result, but instead the fitness of Yoro, who was taken off in the early stages of the second half. The Frenchman appeared to have discomfort in his foot and was comforted by his teammates as he left the field.
Yoro left Old Trafford without a protective boot or crutch, but was seen visibly limping, which has raised concerns about the severity of his injury. United will now nervously be awaiting the results of the teenager's scan, as a lengthy injury would see the defender miss the crucial Europa League final against Spurs.
Yoro was almost nailed on to start the final due to his impressive performances in recent weeks.
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Continental hangover persists
United have looked unbeatable at times in the Europa League and they remain the only team not to have lost a game in Europe this season, however the same can't be said for their league form. Throughout the season, the Reds have struggled to find any kind of consistency in the league, suffering significant defeats at the Theatre of Dreams.
They particularly struggle against physical sides, whereas in Europe they are able to outmuscle their opponents. United are now winless in their last seven league outings and although the club are clearly prioritising the Europa League, their league form is nothing short of unacceptable.
Ahead of the Europa League final, Amorim would have wanted his side to build up some confidence and momentum, however it appears the players aren't playing with any kind of urgency in the league.
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Ugarte's struggles
Manuel Ugarte came to Manchester with some big expectations on his shoulders and after a nervy start at his new club, he slowly began to find his feet. However, in recent weeks his weaknesses have been more evident, to the point where the opposition are now targeting him.
Ugarte, 24, isn't great on the ball, but against West Ham he was too easily dispossessed on multiple occasions. Not only was he poor in possession, but his first touch was often wayward too.
In the build up to Bowen's goal, Ugarte was robbed of possession too easily by former United player Aaron Wan-Bissaka. The Uruguayan was subsequently withdrawn from proceedings for his own good, as it seemed like he was making a mistake in every action.
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Wan-Bissaka excels on return
Wan-Bissaka is one of the only players in recent years, who has left on good terms and continued to perform at a high level at his new club. The full-back was replaced by Mazraoui in the summer, but it was the Englishman who put in a man of the match display on Sunday afternoon.
The defender was deployed as a left wing-back and played a role in the opening goal. Similarly, in the second goal he tackled Ugarte to set up a counter-attacking situation and then provided the assist for Bowen's goal.
He continued to thrive in defensive situations too and he showed his trademark slide tackle on substitute Alejandro Garnacho. A memorable display from Wan-Bissaka on his return to Old Trafford.
