Tottenham Hotspur face what many consider to be a must win Champions League clash against CSKA Moscow in Russia on Tuesday evening.
The Lilywhites fly out for their second game of the group amidst a backdrop of injury worries, with manager Mauricio Pochettino having been forced to seriously reshuffle his pack.
Spurs under pressure after London loss
It's the result that matters most, and whichever group of players are selected to start will be under huge pressure to get one, with Tottenham coming into the game having lost their first game of the group stage.
Indeed, with huge public interest surrounding their return to the Champions League, they lost at home - albeit at Wembley rather than White Hart Lane - by two goals to one against AS Monaco. Toby Alderweireld brought them back into it with a header after they slipped to 0-2 down, but it wasn't enough.
Elsewhere in Group E, CSKA picked up a very credible draw away at Bundesliga side Bayer Leverkusen, widely regarded as the next biggest threat in the group after Tottenham and Monaco. With this in mind, Spurs will want to see off CSKA before travelling to Germany for matchday three.
Injury concerns keep cropping up
Unfortunately for Pochettino, he will be without a number of first team players, with the aforementioned injury list piling up rapidly.
Harry Kane was stretchered off against Sunderland last weekend, with reports ranging from three weeks to two months regarding the supposed length of his injury.
With Kane out, Vincent Janssen is likely to start up front, with in-form man Son Heung-Min out on the left. Dele Alli is likely to partner Victor Wanyama in midfield, with Christian Eriksen ahead and Erik Lamela to the right, as Eric Dier, Mousa Dembele and Moussa Sissoko are all also out injured.
Danny Rose is out too, meaning Ben Davies will probably start at left-back, with the rest of the defensive line looking familiar.
There are a number of recognisable names in the CSKA squad, with ex Premier League players Lacina Traore and Zoran Tosic featuring, as well as Igor Akinfeev and Alan Dzagoev.
Each side second in their league
Although they lost their first game of the group, Spurs do have reason to go into the game full of confidence, as they're flying domestically.
Second in the league, the Lilywhites are still to lose domestically this season and sealed their third consecutive win in all competitions by beating Middlesbrough 2-1 at the Riverside on Saturday afternoon.
Tuesday's hosts have been in good form themselves, and sit second in their own respective league, just one point off the top.
However, they slipped to a defeat in the cup following their draw in Germany two weeks ago, and could only manage a 1-1 draw at home to Krasnodar at the weekend, giving Spurs hope that they'll have enough to clinch the three points.