| Thursday, September 18 | Time EDT | TV | Line (Bovada) |
| Buccaneers (0-2) at Falcons (0-2) | 8:25 PM | CBS/NFL Network | Falcons -7 |
| Sunday, September 21 | |||
| Chargers (1-1) at Bills (2-0) | 1:00 PM | CBS | Bills -1 |
| Cowboys (1-1) at Rams (1-1) | 1:00 PM | FOX | Cowboys -2 |
| Redskins (1-1) at Eagles (2-0) | 1:00 PM | FOX | Eagles -6.5 |
| Texans (2-0) at Giants (0-2) | 1:00 PM | CBS | Texans -1 |
| Vikings (1-1) at Saints (0-2) | 1:00 PM | FOX | Saints -11 |
| Titans (1-1) at Bengals (2-0) | 1:00 PM | CBS | Bengals -7 |
| Ravens (1-1) at Browns (1-1) | 1:00 PM | CBS | Ravens -2 |
| Packers (1-1) at Lions (1-1) | 1:00 PM | FOX | Lions -1 |
| Colts (0-2) at Jaguars (0-2) | 1:00 PM | CBS | Colts -7.5 |
| Raiders (0-2) at Patriots (1-1) | 1:00 PM | CBS | Patriots -14.5 |
| 49ers (1-1) at Cardinals (2-0) | 4:05 PM | FOX | 49ers -3 |
| Broncos (2-0) at Seahawks (1-1) | 4:25 PM | CBS | Seahawks -5.5 |
| Chiefs (0-2) at Dolphins (1-1) | 4:25 PM | CBS | Dolphins -4 |
| Steelers (1-1) at Panthers (2-0) | 8:30 PM | NBC | Panthers -3 |
| Monday, September 22 | |||
| Bears (1-1) at Jets (1-1) | 8:30 PM | ESPN | Jets -3 |
Game of the Week:
Broncos - Seahawks
It's the game that most have been waiting for since the release of the schedule. For only the 6th time, and the first since 1997, there will be a Super Bowl rematch the following season. The Broncos took a severe beating from the Seahawks, 43-8, in Super Bowl XLVIII as Seattle shoved the NFL's top offense around from the first snap.
7 1/2 months later the two teams meet again, this time in Seattle (the Broncos and Seahawks faced each other in the first preseason game of 2014, but the starters played only a couple of series before giving way to the reserves). Both teams have undergone change since the Super Bowl. The 2014 Broncos alone have 10 new starters heading into Sunday's game that weren't in the lineup for the Super Bowl.
One thing that has stayed the same is the home-field advantage for the Seahawks that is still as loud and emotional as ever. The 12th man will be evident come Sunday and may be enough to push the Seahawks over the top.
Each week NFL writers for VAVEL Sports will be making their picks for every NFL game during the season.
| Jarrod Taylor | Michael Pendergraft | Daniel Schmelzer | Mitchell Evans | Addison Hunsicker | Caleb Wahlgren | Harold Connett | |
| TB - ATL | ATL | ATL | ATL | ATL | ATL | ATL | ATL |
| SD - BUF | SD | SD | SD | SD | BUF | BUF | SD |
| DAL - STL | DAL | DAL | DAL | DAL | DAL | DAL | DAL |
| WSH - PHI | PHI | PHI | PHI | PHI | PHI | PHI | PHI |
| HOU - NYG | HOU | HOU | HOU | HOU | HOU | HOU | HOU |
| MIN - NO | NO | NO | NO | NO | NO | NO | NO |
| TEN - CIN | CIN | TEN | CIN | CIN | CIN | CIN | CIN |
| BAL - CLE | BAL | BAL | CLE | BAL | BAL | CLE | BAL |
| GB - DET | DET | GB | GB | GB | GB | GB | GB |
| IND - JAX | IND | IND | JAX | IND | IND | IND | IND |
| OAK - NE | NE | NE | NE | NE | NE | NE | NE |
| SF - ARI | SF | ARI | SF | SF | SF | SF | ARI |
| DEN - SEA | SEA | SEA | SEA | DEN | DEN | SEA | DEN |
| KC - MIA | MIA | MIA | MIA | KC | KC | MIA | MIA |
| PIT - CAR | CAR | CAR | CAR | CAR | CAR | CAR | CAR |
| CHI - NYJ | CHI | CHI | CHI | CHI | NYJ | CHI | CHI |
| Last Week | 11-5 | 8-8 | 7-9 | 7-9 | 8-8 | 6-10 | 4-12 |
| This Week | 12-4 | 11-5 | 9-7 | 11-5 | 9-7 | 9-7 | 11-5 |
| Total | 32-16 | 30-18 | 28-20 | 28-20 | 25-23 | 24-24 | 24-24 |
*Picks in BOLD denote a correct pick.
| Total Offense | ||
| 1 | Philadelphia Eagles | 439 |
| 2 | Atlanta Falcons | 438.5 |
| 3 | New Orleans Saints | 434.5 |
| 4 | Cincinnati Bengals | 426 |
| 5 | Washington Redskins | 410.5 |
| Total Defense | ||
| 1 | Washington Redskins | 234.5 |
| 2 | Detroit Lions | 255 |
| 3 | New York Jets | 274 |
| 4 | New England Patriots | 288.5 |
| 5 | Carolina Panthers | 293.5 |
| Passing | |||
| 1 | Matt Ryan | Atlanta | 679 |
| 2 | Nick Foles | Philadelphia | 653 |
| 3 | Matthew Stafford | Detroit | 637 |
| 4 | Ben Roethlisberger | Pittsburgh | 582 |
| 5 | Drew Brees | New Orleans | 570 |
| Rushing | |||
| 1 | DeMarco Murray | Dallas | 285 |
| 2 | Arian Foster | Houston | 241 |
| 3 | Alfred Morris | Washington | 176 |
| 4 | Le'Veon Bell | Pittsburgh | 168 |
| Terrance West | Cleveland | 168 | |
| Receiving | |||
| 1 | Jordy Nelson | Green Bay | 292 |
| 2 | Calvin Johnson | Detroit | 247 |
| 3 | Antonio Brown | Pittsburgh | 206 |
| 4 | Julio Jones | Atlanta | 204 |
| 5 | Jimmy Graham | New Orleans | 200 |
| Tackles | |||
| 1 | Paul Worilow | Atlanta | 29 |
| 2 | Bobby Wagner | Seattle | 24 |
| 3 | Preston Brown | Buffalo | 20 |
| Dashon Goldson | Tampa Bay | 20 | |
| Jelani Jenkins | Miami | 20 | |
| Sacks | |||
| 1 | Ryan Kerrigan | Washington | 4.0 |
| 2 | Michael Bennett | Seattle | 3.0 |
| Justin Smith | San Francisco | 3.0 | |
| Willie Young | Chicago | 3.0 | |
| 5 | Mario Anderson | Carolina | 2.5 |
| Interceptions | |||
| 1 | Chris Conte | Chicago | 2 |
| Kyle Fuller | Chicago | 2 | |
| George Iloka | Cincinnati | 2 | |
| Jason McCourty | Tennessee | 2 | |
| Rahim Moore | Denver | 2 |