New York hasn't played since defeating Columbus 1-0 ten days ago following the postponement of their Hudson River derby match against NYCFC.
The Red Bulls will be without Cristian Casseres Jr. and Youba Diarra, who are both nursing hamstring injuries. Cameron Harper is questionable with a hip issue. Aaron Long is out for the season with an Achilles injury.
The Fire have only two players listed as out with Ignacio Alaseda missing through a left shin injury and Kenneth Kronholm sideline with a right knee problem.
New York Red Bulls: Coronel; Duncan, Nealis, Tarek, Gutman; Tolkin, Davis; Carmona, Clark; Klimala, Fabio
Chicago: Shuttleworth; Pineda, Calvo, Terán; Navarro, Stojanovic, Herbers, Giménez, Sekulic; Beric, Offor
Ones to watch
Fabio has been a dynamic player playmaker for New York all season, recording three goals and a team-high seven assists. He assisted on both Red Bulls goals in the victory over Chicago earlier this season.
Luka Stojanovic has been the biggest attacking threat for the Fire of late, as the Serbian has scored four goals in Chicago's last four matches, including a pair in the last meeting against New York.
Chicago claimed a 2-1 victory at Soldier Field a little less than a month ago. Stojanovic scored twice inside the first eight minutes with Tom Barlow grabbing a consolation goal for the visitors deep into stoppage time.
The match will be streamed nationally on ESPN+. Coverage in New York will be on the MSG Network and the MSG GO app while WGN-TV will carry all of the action in Chicago. Kickoff is set for 6pm Eastern time.