Adam Buksa returns from suspension to boost a severely depleted Revolution side.
Jon Bell, Brandon Bye, Maciel and Ryan Spaulding all have upper leg injuries and are listed as questionable.
Henry Kessler (muscle) and Andrew Farrell (upper leg) played 90 minutes in erach of the last two matches, but are still listed on the injury report.
Starting goalkeeper Matt Turner is eyeing a May return from a lower leg issue while Gustavo Bou looks to be a week away from a comeback nursing an upper leg issue.
The expansion club are considerably healthier than their hosts with Vinicius Mello out after having surgery on his left foot and Chris Hegardt recovering from lower knee surgery.
Kamil Jozwiak has a lower leg injury and awaits his team debut after signing as a Designated Player from EFL Championship side Derby County.
New England Revolution: Knighton; Spaulding, Farrell, Kessler, Jones; Polster, McNamara; Traustason, Gil; Lletget, Rennicks
Charlotte FC: Kahlina; Mora, Fuchs, Corujo, Lindsey; Bender, Bronico, Franco; Alcívar; Ríos, Swiderski
Ones to watch
Adam Buksa (New England)
Last year's leading scorer with 16 goals is desperately needed with so many key players sidelined. He scored twice in the CONCACAF Champions League, but has yet to find the back of the net in league play, recording just a pair of assists.
Karol Swiderski (Charlotte FC)
The Pole has provided the offensive spark that Charlotte needs, tallying four goals and an assist in six appearances this season. He scored twice and had an assist in the first meeting against New England.
Less than a month ago, Charlotte came away with a surprising 3-1 victory at home, their first at Bank of America Stadium.
Swiderski scored the franchise's first-ever goal when he blistered one past Turner from outside of the box.
Carles Gil equalized from the penalty spot in the 54th minute from the penalty spot, but Swiderski's second of the match proved to the winning goal and Ben Bender added a third.
The match will be streamed nationally on ESPN+. TV38 and RITV will carry all of the action in New England while WAXN provides English-language coverage, Telemundo presenting the match in Spanish.
Kickoff time is set for 7:30pm Eastern time.