The last time these two sides met was on the last day of the 2017/18 season in a nine-goal thriller.
However, Mauricio Pochettino's side have numerous new injuries ahead of the tie and with a trip to Barcelona on Tuesday he has a lot to consider.
Ahead of the Leicester tie, Jan Vertonghen will return to the side after serving his one-match ban.
However, Pochettino spoke of the fresh injuries picked up this week:
"I think it is only to not take a risk about him (Juan Foyth) and then for sure Saturday he is out. Tuesday he cannot play because he is out of the list and then I am sure he is going to be ready for the next game.
"After he (Kieran Trippier) came off on Wednesday I think first of all we need to try… We are creating a plan for him to try to help him improve. If we apply common sense, it’s difficult for tomorrow to play when you come off," the 46-year-old added.
The Argentine coach also mentioned the ongoing injury to Erik Lamela:
"Erik, I think tomorrow or after tomorrow will again be with the group training and may be available for Tuesday to be selected. One thing we need to understand with Lamela is that he suffered a massive problem, remember it was more than one year out."
The Foxes have proven a tricky customer in the past for Spurs and Pochettino is not expecting an easy ride on Saturday:
"I think Leicester are a very good team. After the tragedy, it is such a difficult thing to recover from.
"We are so painful and so sorry for everyone there. But they have a great manager, great players," he said.
Spurs narrowly edged a 5-4 win at Wembley last season against the Foxes after coming from behind on three occasions.
"I think they have a very good squad. It is a team that plays so well with clear ideas. Of course, they are doing a fantastic job. It is not easy. For me, it is going to be a tough game."
Barça on Tuesday
Yet, Pochettino believes their focus has to be on Saturday's game:
"No, I think the focus for us is to try to win the three points against Leicester. That is the most important game. It doesn’t exist, Barcelona.
"We’re going to maybe rotate some players because they need rest, not because we’re going to play against Barcelona on Tuesday," he said.