Meanwhile, Championship side Bournemouth avoided being on the wrong side of an upset as they managed to get a convincing 4-1 win against Oldham Athletic to reach this stage, Josh King starring with 2 goals and an assist.
Bournemouth have a fully fit squad ahead of this tie, but may look to rotate, including giving Jack Wilshere his first start after rejoining last week.
Dan Gosling may also get a start amid rumours of a move to Nottingham Forest.
Crawley have five players that tested positive for Covid-19, after an outbreak at their training ground last Tuesday.
Dennis; Stacey, Carter-Vickers, Simpson, Zemura, Billing, Kilkenny, Gosling, Brooks, King, Riquelme.
Morris; Dallison, Tunnicliffe, Craig, Davies, Francomb, Hessenthaler, Matthews, Powell, Nichols, Nadesan.
Ones to watch
The Norwegian has only started four times in the league and has found game time limited this season, but he still undoubtedly has the quality to play in the Premier League, with West Bromwich Albion reportedly interested.
With the departure of Max Watters, Town will have lost 13 goals in all competitions, but they need someone to step up and provide the goals, and Nadesan can certainly do that. He lead the line very well against Leeds, scoring and assisting once, so they will be hoping he can do the same.
These two have only met twice in their entire history, both back in 2012 in League One as Bournemouth won back-to-back promotions from League Two all the way to the Championship. Crawley won 3-1 the first time, while Bournemouth won 3-0 in the reverse fixture.
How to watch
The match will kick-off at 19:00 pm on Tuesday, January 26, and is available to watch on BT Sport Extra.