Before playing Burnley earlier this year Jurgen Klopp's men had accumulated a 68 game unbeaten run at Anfield. However, since then the Reds have lost two home games on the bounce, the first time since 2012.
Klopp and his players will be desperately looking to get back to winning ways especially against Pep Guardiola's Man City.
This may prove difficult with City sitting three points clear with a game in hand at the top of the Premier League table.
City are currently on a 13 game unbeaten run in the league and don't show any signs of slowing down despite losing their talisman Kevin de Bruyne through injury.
Naby Keita, Joe Gomez and Virgil van Dijk all still remain out as well as Diogo Jota who has begun individual training at Kirkby.
Not a lot has changed for City as De Bruyne, Nathan Ake and Sergio Aguero are the only players who will miss out on the match.
Liverpool (4-3-3): Alisson, Alexander-Arnold, Henderson, Fabinho, Robertson, Wijnaldum, Thiago, Jones, Salah, Firmino, Mane.
Manchester City (4-3-3): Ederson, Cancelo, Stones, Dias, Zinchenko, Gundogan, Rodri, Silva, Foden, Sterling, Jesus.
Ones to watch
Mohamed Salah will be looking to replicate what he did in the reverse fixture and bag himself another goal. The Egyptian is currently the Premier League top goal scorer with 15 goals.
He will be looking to add to this tally after he failed to score in Liverpool's previous match against Brighton. Liverpool have also failed to score in their last three home games and will be looking to their start striker to come out on top.
A player to watch for City is Ilkay Gundogan. The German midfielder has filled the boots of the injured De Bruyne and shone for City in recent weeks.
He will be looking to continue his fine form against Liverpool on Sunday.
The reverse fixture saw a stalemate at the Etihad. Salah's penalty opened up the scoring before Bernado Silva cancelled out his goal to level the score for City.
Klopp will be hoping to come away with all three points this time around at Anfield.
Where to watch on TV
The match will be shown live on Sky Sports Main Event and Sky Sports Premier League. Coverage starts at 4pm with kick-off at 4:30pm.