Southampton striker Danny Ings would get the first goal of the evening, after his low effort was saved by back-up Wolves goalkeeper, John Ruddy, which kindly fell back to Ings who's standing leg would knock the ball past the Wolves keeper.
Ruddy would be involved heavily in the second goal as he gave the ball needlessly to Saints youngster Nathan Tella, who in turn gifted the ball to Stuart Armstrong to guide into a net guarded by the helpless Roman Saiss.
What exactly went wrong for the Midlands side at Southampton?
Wolves need to keep their focus
In recent press conferences, Wolves manager, Nuno Espirito Santo, has been adamant that his players need to start keeping their focus at crucial stages in games to be able to get the results they need.
Nuno would not have been happy with his team's focus today by any stretch of the imagination. In a game full of defensive mishaps and misplaced passes, there is no doubt that some of the players mentally were not fully focused on the task at hand.
At the back, there were multiple moments of lost focus leading to chances at goal, the worst of which being the Ruddy mistake that ultimately led to the Saints securing the tie and heading into the next round.
Wolves need to get their focus back, doing this would almost guarantee that there would be no mishaps or moments of miscommunication amongst the squad, inevitably leading to the better results that Wolves fans are craving.
Southampton's attacking threat was superior
The Saints are in a good position when it comes to attacking talent, they have players who are willing to go an extra mile and are willing to keep running for that final ball.
Nathan Redmond, Ings and Moussa Djenepo were at the heart of the Saint's dagger and would run at Wolves' defence at every opportunity that came to pass.
The Wolves defence looked in deep water all evening and struggled to get to grips with the Southampton livewire.
The back three had no answers to any of the questions that the Saints attackers were proposing, opening spaces for the final ball to be played through and making themselves vulnerable.
Wolves lacking creativity
There was a distinct lack of creativity on show at Molineux for the visitors, with the final pass being lacklustre on several occasions.
Frustration for the fans grew as time and time again there was a lack of consistency with the final ball struggling to find a way to get a shot off at the opposing goal.
If Wolves are to improve on recent performances there must be some consistency in the final ball and in the build-up lay for the Midlands side.
A quiet night for Wolves could have been so much different if the midfielders and attackers were able to conjure that last ball up and be in the running to fight in the FA Cup.
Overall, a very underwhelming night for Wolves players and fans as they crash out of the FA Cup with no real fight being shown on the night.