Pompey currently sit in fourth position with a four point buffer over Accrington Stanley in the last spot outside of the play-off places. Meanwhile, Gillingham are 11 points worse off in 15th position, unlikely to find themselves in a relegation battle but also with little chance of earning promotion at this stage.
Portsmouth have the benefit of no fresh injury concerns going into the game. Alex Bass, Michael Jacobs and James Bolton remain absentees for the Hampshire side.
Gillingham manager Steve Evans will be without on loan Southampton midfielder Callum Slattery at the weekend. The 22-year-old will be out for three weeks after he suffered bruised ligaments from rolling his ankle in the 2-0 victory over Bristol Rovers.
MacGillivray - Johnson, Raggett, Nicolaisen, Brown - Harness, Naylor, Cannon, White - Curtis, Harrison.
Bonham - Jackson, Cundy, Tucker, Ogilvie - O'Keefe - Graham, Dempsey, O'Connor - Oliver, Akinde.
Portsmouth got back to winning ways in midweek after suffering two losses in a row beforehand to Bristol Rovers and Blackpool. A tight 1-0 win over Oxford United would have boosted the mood around Fratton Park, combined with the fact manager Kenny Jackett will return to the sidelines for the first time since undergoing arm surgery last week.
Gillingham have been in mixed form of late with two wins and three losses in their last three matches. They'll be hoping to pull of a bit of an upset to bounce back from the loss to AFC Wimbledon.
Ones to watch
Ronan Curtis may be the one to watch for Portsmouth. The lively winger has proven a handful for many teams contributing eight goals and six assists this season. He also showed versatility when moved to the striker position alongside Ellis Harrison in the victory over Oxford United.
For Gillingham the one to watch will be Jordan Graham. He tops the charts for goals and assists for the Gills this season, and will provide a threat that any opposition defence will need to take extra care of.
The two sides last met in the reverse fixture this season back in October, where Portsmouth won 2-0 at the Priestfield Stadium. Two efforts in the space of three first-half minutes from John Marquis and Michael Jacobs were enough to send the points Pompey's way that evening.
Portsmouth also lead the way significantly in the overall head-to-head record, with 20 wins compared to the Gills' nine. There have also been nine occasions where the points have been shared between the two sides.
How to watch
The game has not been selected for TV coverage in the UK, but an iFollow pass can be purchased for £10 via either club’s website to stream the game live.
Kick-off is scheduled for 15:00 GMT.