Next up for them is a home tie against outside play-off hopefuls, Plymouth Argyle who are on an excellent run of form having lost just once in their last 11 outings.
Both teams are looking for three very important points as the Cobblers look to scramble out of the relegation zone and Plymouth try to close in on the top six.
• Team news
There are no fresh injury updates for Jon Brady's Cobblers, with midfielder Scott Pollock being the only confirmed absentee.
Interim boss Brady is still trying to find out what his best XI is and has swapped between 3-5-2 and 4-3-3 since he took charge.
After starting with a back four in Saturday's defeat to Swindon Town, it is likely he will revert back to a 3-5-2 with Cian Bolger and Shaun McWilliams potentially returning to the starting XI from the bench.
For Plymouth, George Cooper and Gary Sawyer have both been ruled out of Tuesday's clash as they both recover from injuries.
Ryan Lowe could however stick with the same XI that served him well against the Imps after an impressive 4-3 win on Saturday afternoon.
• Predicted lineups
Mitchell; Horsfall, Bolger, Jones; Kioso, McWilliams, Sowerby, Mills; Hoskins; Rose, Marshall.
Northampton could play in a 3-4-1-2 formation with Peter Kioso and Joseph Mills playing as wing-backs, Sam Hoskins will operate in the number ten role and Mark Marshall could partner Danny Rose up top.
Cooper; Watts, Opoku, Aimson; Moore, Mayor, Fornah, Camara, Grant; Ennis, Jephcott.
Plymouth also like to utilise a back three but with a flat five across the middle and two up front. Jephcott is likely to partner Niall Ennis as the two strikers and Panutche Camara could start after an influential performance off the bench on the weekend.
• Ones to watch
28-year-old, Sam Hoskins is one of Northampton's most important outlets in their attacking department.
The Englishman has scored three goals and notched five assists so far this campaign and although the Cobblers are not doing particularly well this season, if Hoskins performs well, he could be the difference on the night.
Hoskins has great physical strength as well as an emphatic change of pace. He has the ability to take on and cause defenders problems and his quality in the final third has been important in the games Northampton have done well in this season.
The midfielder has helped the Cobblers create 36 chances this season and he has made 31 key passes. His ability is certainly of a dangerous level and if he manages to find some form and confidence, he could cause Plymouth defenders some issues on Tuesday night.
Jephcott has been instrumental for Argyle this season having scored 16 goals so far this campaign.
At just 21 years of age, Jephcott has proved he has a deadly instinct for sniffing out goalscoring opportunities and the quality to put away chances.
Of his 16 goals, ten of them have been powered home with his preferred right foot, four have been with his left and he has nodded the ball home twice with his head.
All of his goals have come from inside the penalty area and he has been a constant threat to opposing defenders when the ball breaks in the 18-yard box.
Jephcott has the ability to not only score goals but he creates opportunities as well. His ability to hold the ball up and bring others into play has been excellent this season and he has been a real handful for many teams.
• Previous meetings
Out of the last 14 meetings between these two sides, Northampton have won four times, Plymouth have won nine and there has been one draw.
The last nine times these two have played there has been two or more goals.
When they played earlier on in the season Plymouth won 2-1 with goals from Frank Nouble and Kelland Watts cancelling out a Ricky Korboa equaliser.
Last time out:
• Where to watch
This game kicks off at 19:00 BST on Tuesday 2 March 2021.
For Cobblers fans, the game can be watched by purchasing a live video match pass from the iFollow section of their website found here.
The same process can be followed by Plymouth fans with their iFollow being found here.
Both are for a cost of £10.