The visitors come into the game on a ten match unbeaten run, and will be looking to make it eleven after a 4-0 thrashing of Derby County.
Huddersfield manager Carlos Corberan will be without a number of first teamers as Rolando Aarons, Carel Eiting, Tommy Elphick, Danny Grant, Jonathan Hogg, Josh Koroma, Alex Pritchard, Christopher Schindler, Harry Toffolo and Danny Ward have all been out since suffering their respective injuries.
The Bluebirds will be without Joe Bennett after he suffered an anterior cruciate ligament injury in their 4-0 win against Derby. Lee Tomlin also remains out after his groin surgery back in November.
Huddersfield Town (4-3-3)
Schofield, Edmonds - Green, Stearman, Sarr, Pipa, Bacuna, Vallejo, O'Brien, Holmes, Campbell, Mbenza.
Cardiff City (3-4-3)
Phillips, Morrison, Flint, Nelson, Ng, Vaulks, Pack, Bagan, Ojo, Bacuna, Moore.
Ones to watch
Since making a permanent move back to Huddersfield Town in January from Derby County, Holmes has featured eight times for the Terriers and has scored two goals.
One of his goals for Huddersfield was a screamer against Swansea City last month, and he will be hoping he can continue his good form.
Since making the move to Wales in the summer from Wigan Athletic, the Wales international has been in fabulous form for the Bluebirds.
He has scored 16 goals in 30 games and has contributed with two assists, and the Huddersfield defence will need to be on top form to stop him.
The last time the two sides met Cardiff eased to a 3-0 victory at the Cardiff City Stadium. Huddersfield haven't beaten Cardiff in 14 games in all competitions, with Cardiff winning ten and the other four ending in draws.
Due to the current National Lockdown, there will be no fans in attendance when the two sides meet at The John Smith's Stadium on Saturday. This means the game will be available on iFollow through Huddersfield's and Cardiff's respective websites, with passes priced at £10.
The game kicks off at 15:00 GMT on Saturday 6 March 2021.