The Posh sit three points clear at the head of the table, with two games in hand on their closest rivals in second place Hull City.
The Brewers have leaped from rock bottom, all the way to 18th place after a tremendous run under their former boss Jimmy Floyd Haselbaink, who was reappointed in January.
However, free-scoring Peterborough come to the Pirelli with the best defence in the league. Darren Ferguson's side are also the second most prolific side in the league.
Haselbaink has a full squad to choose from once again, with one exception. Ryan Broom is ineligible to play on Saturday, as he is on loan from Peterborough.
However, for the Posh, they're sweating over two star players. It seems Jack Taylor will be out, with Ethan Hamilton set to come in, in midfield. Also, Ferguson is worrying that top scorer Jonson Clarke-Harris might not be fit for the game after an ankle problem. It would be a huge boost for the Leicester-born striker to be fit.
Burton Albion (4-5-1):
Garratt; Brayford, Carter, Bostwick, Hamer; Smith, Edwards, Mancienne, Clare, Akins; Fondop-Talom.
Pym; Butler, Beevers, Kent, Thompson; Ward, Hamilton, Brown; Dembele, Szmodics; Clarke-Harris.
Ones to watch
Jonny Smith signed for the Brewers in January for an undisclosed fee. In six appearances the 23-year-old has scored twice. Including a goal in his debut match on February sixth, where he scored the only goal of the match to win, against then top of the league Hull.
Smith also scored the only goal of the game against Bristol Rovers this past Tuesday night, and what a belter it was.
With his blistering pace on the right wing, and the ability to cut in on his left foot he will be sure to cause Posh some problems, and could play a key part in the game.
Jonson Clarke-Harris has been a cult hero this season for the Cambridgeshire side. Scoring 21 goals in 31 appearances, he has been clinical as ever. Showing why he got the move, after scoring over 20 goals last season for Bristol Rovers.
The 26-year-old can do it all, score with his left, his right, his head and even has a couple of goals from a free-kick.
His power and physical presence could cause a real problem for Burton's defence, if he is deemed fit to play. It would certainly be a let off for the Brewers if he couldn't play.
Coming from the background he does, making his professional debut for Coventry 10 years ago at 16, he's got bags of experience playing at a high level in the EFL.
When the sides met back in October, the points were shared in a fascinating game at the Weston Homes Stadium. It finished 2-2 with Kane Hemmings getting a brace to pull it back twice for the visiting Burton.
How to watch
Due to current lockdown restrictions, there will be no fans in attendance and the game can be watched via iFollow where passes can be purchased on club websites for £10.