Bournemouth come into this game in good form after beating promotion candidates Swansea 3-0 on tuesday. An inconsistent season from the cherries means they currently sit just out the play -off places in 7th.
Sitting in 14th, Saints need a good result against their south coast rivals to shine some light on a season filled with more negatives than positives. A lack of goals from Ralph Hassenhuttl's team has been the problem, which has seen them slide down the table after sitting in 1st during November.
Team News - Southampton FC
Southampton are still without talisman Danny Ings; a big blow for Hassenhuttl.
Theo Walcott is also absent through injury, as well as Oriel Romeu who is sidelined till the end of the season with a knee injury.
Team news - AFC Bournemouth
Bournemouth are still without David Brooks, as well as Lewis Cook and Adam Smith.
Over the last five meetings, Southampton have enjoyed the south coast derby more, winning twice and drawing once. The most recent fixture was a 2-0 win to Southampton, at the Vitality Stadium.
Ones to watch
Southampton FC - Che Adams
Adams has been in good form recently, scoring three in his last three league games, and will be key to Saints success in the absence of his strike partner Ings.
AFC Bournemouth - Arnaut Danjuma
Danjuma has been on fire recently scoring 4 in his last 5 league games, and is a big part in Bournemouths promotion hopes. He is currently Bournemouth's second top scorer with ten goals; and also four assists to his name.
Southampton FC (4-4-2): Forster; Walker-Peters, Bednarak, Vestegaard, Bertrand; Minamino, Ward-Prowse, Diallo, Armstrong; Adams, Redmond
AFC Bournemouth (4-2-3-1): Begovic; Rico, Cook, Carter-Vickers, Stacey; Wilshire, Lerma, Stanislas, Billing, Danjuma; Solanke
How to watch
AFC Bournemouth vs Southampton FC will take place at 12:15pm on saturday 20th March at the Vitality Stadium, and will be shown on BT Sport.