Both teams were disappointing last season in the end, so will be looking to do a lot better this time out.
Reading will have Ovie Ejaria returning to the squad after he missed out at Stoke through injury. New loan signing Tom Dele-Bashiru could be in line to make his debut after signing from Watford on Thursday. Yakou Meite and Felipe Araruna are both still out.
Rafael; Yiadom, Morrison, Moore, McIntyre, Rinomhota, Laurent, Azeez, Swift, Ejaria, Joao.
Iversen; Storey, Lindsay, Hughes, Barkhuizen, Whiteman, Ledson, Browne, Cunningham, Evans, Maguire.
Ones to watch
The trickster was a huge miss for the Royals last weekend, as they lacked some flair going forward. The mass dribbler will always get past a player or two and is key to bringing the team forward when attacking. His return could be key to Reading's result
The Dane struggled in his first season in England but has already started scoring this season. He has scored two of Preston's three competitive goals so far this season, and he could be their talisman this season after the faltering form of Sean Maguire.
The last two times these sides met was back at the end of January, where the two sides drew 0-0 after Lucas Joao missed a penalty late on.
How to watch
Unfortunately, this game is unavailable to watch for those in the UK, but you can watch it if you live internationally by paying £10 on Reading or Preston's website.