The Red Devils on the other hand have had a good start to the season, winning and drawing a game so far but will be boosted by the arrival of the four time Balon d'or winner Cristiano Ronaldo from Juventus.
The last time the two sides faced was on 23rd May 2021, which saw Juan Mata sealing the 2-1 win for United.
Bruno Lage's Wolves are once again going to be without star winger Pedro Neto, as well as Jonny, Yerson Mosquera and Bueno for this fixture.
In the last week, Lage has revealed that centre half Willy Boly is back in training for the midlands side which will be a huge boost to their defensive assets. Despite being back in full training, he is unlikely to feature this week, but is looking to be back after the international break.
Jose Sa is almost certain to start in goal for Wolves after arriving from Olympiacos in the summer to replace fellow countryman Rui Patricio, who moved to Roma. At the back, Wolves are likely to stick with the three centre backs of Conor Coady, Max Kilman, Romain Saiss with the full backs being Nelson Semedo and Marçal.
Ruben Neves is also likely to continue in the midfield and will be Wolves' main man to control the tempo of the game, and will probably be partnered by Joao Moutinho who featured in the Carabao Cup game in midweek.
In the front three, Adama Traore has been Wolves' best player this season, and will continue out on the right hand side, with Francisco Trincão playing out on the left, looking to rotate and find holes in the United defence. Raul Jimenez is likely to start up front for Wolves, continuing his comeback from his nasty skull fracture injury last season.
Wolves' XI: Sa, Coady, Saiss, Kilman, Semedo, Marçal, Neves, Moutinho, Traore, Jimenez, Trincão.
Travelling Manchester United are going to be without a whole host of players who could offer them more options in the side. The list of absent players is: Alex Telles, Dean Henderson, Eric Bailly, Marcus Rashford, Phil Jones, Scott Mctominay with Amad Diallo and Anthony Elanga also doubtful.
David De Gea is likely to start for the visitors, with the defence probably going to feature new signing Raphael Varane from Real Madrid.
Nemanja Matic and Fred are likely to start in the centre of midfield for Manchester United, alongside Paul Pogba who has been brilliant so far this season, already racking up four assists in the first two fixtures. Bruno Fernandes will start in the midfield as well, who has been the star player at the club since his arrival.
New signing Jadon Sancho is likely to get his first start since arriving in the summer from Borussia Dortmund for £70 million. He will be a huge threat for Wolves down the right hand side, and will occupy full back Marcal reducing him as an attacking option for Wolves.
Up front Mason Greenwood is likely to continue up his run in the first team, after impressing in the opening two games of the season and scoring in them both.
Manchester United XI: De Gea, Wan-Bissaka, Varane, Maguire, Shaw, Matic, Fred, Pogba, Fernandes, Sancho, Greenwood.