The Potters will hope to continue their fine home form, with four wins from four at the bet365 Stadium in all competitions so far this campaign.
Like their hosts, Huddersfield Town have also begun the season with a spring in their step despite being tipped to struggle by pundits and fans alike.
Carlos Corberan's men also have 10 points and sit one place above the Potters in fourth position, after a comprehensive 4-0 win against Reading last time out.
The Potters' key man Nick Powell remains on the sidelines with a thigh injury picked up against Swansea City in mid-August.
Stoke fans will have to wait to watch new signing Abdallah Sima in action, after he could not gain his Visa in time to train before Saturday's game.
Tyrese Campbell and Tashan Oakley-Boothe are both edging closer to a return, but will not be involved against Huddersfield.
For the visitors, winger Aaron Rowe has returned to training but will not be available for the trip to the Potteries.
Striker Danny Ward is a doubt after a hip irritation, and is to be assessed to see if he is fit to play against Stoke.
Bursik; Ostigard, Souttar, Wilmot; Smith, Allen, Vrancic, Doughty; Clucas; Brown, Surridge.
Nicholls; Pearson, Lees, Colwill; Thomas, High, Hogg, O'Brien, Toffolo; Odubeko, Koroma.
Ones to watch
With Michael O'Neill officially adopting a three at the back system for the 21/22 campaign, new life has since been breathed into Josh Tymon's Stoke career. The 22-year-old has been at the club since 2017, but struggled to nail down a spot in the matchday squad with many questioning his best position and his defensive qualities as a left-back.
Now deployed as a wing-back, Tymon looks to have cemented his spot in the starting XI for the foreseeable future after scoring his first goal for the club against Nottingham Forest and winning the club's August Player of the Month award for his performances.
Also 22, Thomas has enjoyed a rapid rise to stardom in recent months after plying his trade in non-league with Boreham Wood from 2017 to January 2021. The Terriers then took a gamble on the winger, and so far it looks to have massively paid off.
Pacy, direct and always on the move, Thomas has come into his own so far this season - with his one goal and four assists enough to see him named the Sky Bet Championship Player of the Month for August. The Potters defence will need to be on high alert to stop him from adding to his tally.
The last game between the two ended 1-1, with goals from Pipa and Steven Fletcher respectively.
This fixture has certainly not been short of goals in recent years, with 16 in the previous three games.
The game at the bet365 Stadium last season saw Stoke run out 4-3 winners in November.
How to watch
The game kicks off at 15:00 BST on Saturday September 11.
Fans based overseas will be able to watch a live stream of the game, with match passes from £10 available on Stoke's website.