The Hoops drew 1-1 last time out against Blackpool with Chris Willock getting on the scoresheet, they currently occupy the final play-off spot. The Hatters, who are 11th in the table, lost 1-0 to Stoke City.
Luke Berry was scheduled to return from a knee injury following the international break, but the Luton midfielder is a doubt to make the trip to London. Fred Onyedinma could be recalled to start in a three-run midfield.
Queens Park Rangers: Dieng; Dickie, Dunne, Barbet; Adomah, Dozzell, Johansen, Odubajo; Chair, Willock, Dykes
Luton Town: Sluga; Naismith, Bradley, Burke; Bell, Mpanzu, Osho, Bree; Onyedinma; Cornick, Adebayo
Ones to watch
Lyndon Dykes (Queens Park Rangers)
With five goals in 11 appearances this season, the scoring burden will be placed on the Australian, especially with Gray out and Chair undergoing evaluation prior to the match.
Allan Campbell (Luton Town)
He returned to the starting line-up for the first time since suffering ligament damage against Blackburn Rovers and was easily the Hatters' best player in the defeat to Stoke, especially defensively, closing down areas of the pitch well while showing a real energy and enthusiasm to his play.
QPR did the double over Luton last season in dominant fashion, outscoring the Hatters in the two matches.
Four months later, QPR ran out 3-1 winners in the reverse fixture. Austin opened the scoring before Kiernan Dewsbury-Hall leveled two minutes before halftime.
How to watch
The match will be televised on Sky Sports Football with coverage beginning at 19:00 GMT. Kick-off is set for 19:45.