Northampton are two points off the automatic promotion places and are still searching for their first win of 2022 after struggling to regain form since their Christmas schedule was interrupted by members of the squad contracting COVID-19.
Play-off chasing Salford are four points outside of the play-off places and are in good form on the road having lost only one of their four away games in January.
The Cobblers suffered a huge injury blow on the road against Sutton United last weekend when Cardiff City loanee Chanka Zimba suffered a hamstring injury which will keep the forward out for six weeks.
Full-back Joseph Mills has been recovering from an ankle injury since September and despite being back on the bench in recent times, the 32-year-old has had a setback with his ankle and is unlikely to feature on Saturday.
The hosts will be boosted by the signing of forward Idris Kanu who joined the club on loan from Peterborough United this week.
As for Salford, they will be without striker Tom Elliot on Saturday after he was loaned out to fellow League Two side Bradford City this week.
Influential winger Josh Morris is also a doubt for Gary Bowyer's side on Saturday.
Matty Willock, Ian Henderson and Luke Burgess are also sidelined due to injuries.
Northampton Town (4-3-3): Roberts, McGowan, Guthrie, Horsfall, Koiki, Sowerby, McWilliams, Lewis, Pinnock, Hoskins, Kanu.
Salford City (4-2-3-1): King, Shephard, Eastham, Turnbull, Ndaba, Lund, Lowe, Love, Watson, Hunter, Smith.
Ones to watch
The Cobblers have looked dangerous from set-pieces so far this season and defender Jon Guthrie has been instrumental in getting goals from dead-ball situations for Northampton.
The Cobblers centre back is Northampton's second top scorer with six goals having shown plenty of power in the air in opposition boxes this season.
Guthrie last netted for the Cobblers on New Year's Day in their 5-2 defeat to Swindon Town, a goal which put his side 2-1 up at the time in the match.
For the visitors, midfielder Matthew Lund will be one to keep an eye on come Saturday afternoon.
Northampton will be well aware of the threat Lund poses as he scored in the reverse fixture against the Cobblers in September.
Lund has netted five times for The Ammies but hasn't scored yet for Salford since the turn of the year and will be eager to get off the mark for the new calendar year this weekend.
Northampton will take confidence from the fact they have never lost to Salford in the three occasions they have faced them.
The last time the sides met was in the reverse fixture this season which ended 2-2 at The Peninsula Stadium.
Where to watch
While the game is not available to watch live in the UK, overseas supporters can watch the game via either clubs' iFollow service.
Supporters in the UK can use iFollow to listen to the match live.