The Cobblers currently sit two points off third and are looking to build momentum following their first win of 2022 against Salford City on Saturday.
Their visitors, Barrow, will also be eager to get back to winning ways having won only once in January leaving them 21st in League Two, seven points clear of the relegation zone.
Northampton will be boosted by the signing of Bez Lubala who joined the Cobblers on loan from Blackpool on deadline day with another addition expected before the end of the window according to the Northampton Chronicle and Echo.
Jordan Flores will not be available for the hosts after having his contract terminated on deadline day.
Barrow will also be boosted by a new addition of their own after their resigned John Rooney for an undisclosed fee from Stockport County on Sunday.
The Bluebirds are struggling with injuries at the moment having only named six players on the bench for their defeat to Newport County at the weekend.
Northampton Town: Roberts, Koiki, Guthrie, Horsfall, McGowan, Sowerby, Lewis, McWilliams, Hoskins, Eppiah, Pinnock.
Barrow: Farman, Hutton, Jones, Platt, Brough, Glennon, Banks, White, Beadling, Amadi-Holloway, James.
Ones to watch
Paul Lewis has contributed plenty of goals from midfield for the Cobblers this season.
Lewis helped make the difference on Saturday when his shot rebounded to Jon Guthrie who scored the only goal in the Cobblers 1-0 win over Salford on Saturday.
Jon Brady's side have struggled to find that cutting edge up top but Lewis' goals from midfield could prove crucial in his side gaining promotion.
Lewis has six goals so far this season.
Barrow have a midfield goalscorer of their own, Ollie Banks is the Bluebirds top scorer this season and his goals have helped his side pull seven points clear of the relegation zone.
Banks will be keen to prove his worth when he returns to his former club Northampton on Tuesday.
The midfielder spent the 2014-15 season on loan with the Cobblers but only made three appearances during his time at Sixfields.
Barrow will travel to Northampton hoping to turn around their terrible record against the Cobblers.
The sides have met 14 times previously with ten Northampton wins, one draw and three wins for Barrow.
The last time the sides met was in October 1971 at Sixfields where Northampton ran out 2-0 winners in a Division Four clash.
Where to watch
While the game is not being broadcast live on TV, both sets of supporters can watch the game live via their club iFollow service.