Northampton beat Newport in midweek to move into the automatic promotion places and currently sit third.
Port Vale: Holy; Smith, Walker, Martin; Worrall, Pett, Garrity, Hussey; Wilson, Edmondson, Harratt.
Northampton Town: Roberts; Magloire, Horsfall, Guthrie; Hoskins, McWilliams, Lewis, Koiki; Pinnock; Eppiah, Appere.
Ones to watch
Leeds United loanee Ryan Edmondson will be one to watch for the Valiants on Saturday.
Edmondson spent the first half of the season on loan at Fleetwood Town but was recalled by Leeds and made the move to Vale Park in January.
The striker scored his first goal for Vale in their 1-1 draw with league leaders Forest Green Rovers on February 1.
The 20-year-old will have a point to prove on Saturday following a disappointing loan spell with Northampton during the second half of last season when he was part of the Cobblers side to be relegated from League One.
As for Northampton, defender Fraser Horsfall will be a threat for the Cobblers at the weekend.
While it may seem surprising that a defender is being highlighted as a danger man, Northampton have been excellent from set pieces this season and Horsfall has five goals for the Cobblers this season, his most recent was against Newport in midweek.
This fixture certainly has plenty of history with 76 previous meetings.
Northampton have the upper hand with 30 wins, 22 draws and 24 Vale wins.
The last time the sides met was back in August on the opening day of the season with Northampton winning by a goal to nil, Vale's first defeat against the Cobblers since March 2017.
Where to watch on TV
While the game is not available to watch live in the UK, overseas supporters can watch the game via either clubs' iFollow service.
Supporters in the UK can use iFollow to listen to the match live.