They currently sit bottom of the Championship table, seven points from safety.
Stoke City have seen their season dwindle away in recent weeks and Michael O'Neill's side now have little to play for other than pride as the season enters its final stages.
The Potters sit 15th in the table having won just one of their last 10 league games.
The Posh are without on-loan goalkeeper Steven Benda for the next three weeks after he picked up a back injury two games ago.
Nathan Thompson is set to miss the rest of the season with a shoulder injury.
Dan Butler is also missing for the remainder of the season with a hamstring injury.
Phil Jagielka has trained this week after a slight groin strain and should be ready to play again.
Morgan Fox has now served a three-match suspension, but has been nursing an ankle injury that will see him sidelined for the next three games.
Liam Moore (knee) and Tommy Smith (ankle) are both major doubts.
Nick Powell (quad) is set to be out for six weeks with a quad injury.
Harry Souttar remains sidelined for the rest of the season.
Peterborough United (3-4-1-2)
Cornell; Kent, Knight, Edwards; Ward, Taylor, Norburn, Burrows; Fuchs; Marriott, Clarke-Harris.
Stoke City (3-5-2)
Bonham; Jagielka, Harwood-Bellis, Chester; Smith, Allen, Baker, Sawyers, Tymon; Brown, Maja.
Ones to watch
27-year-old Marriott is a name well-known to Championship fans for his time at Derby County from 2018-2021 where he scored 17 goals in 86 games. He joined the Rams from Peterborough in 2018, after scoring 33 goals in 56 games for the Posh in just one season.
Darren Ferguson re-signed him from Derby last summer, and his second spell has not been quite as successful so far. He has notched four in 17 games in an injury-hit campaign, but will look to build on his goal at Bournemouth in midweek.
Baker arrived in Staffordshire in January, and his good form since joining has seen him win the club's Player of the Month award for February. He departed Chelsea in the window after being contracted with the club since 2014, making just two appearances in that time.
His most notable loan spells have been at Vitesse, Reading and Trabzonspor, where he picked up a Turkish Super Cup medal in 2020. The 26 year-old has scored five goals in his first 11 games for Stoke, despite being employed in a holding midfield role.
The Posh have never beaten the Potters in their history, with eight Stoke wins and five draws.
It is Stoke's first visit to the Weston Homes Stadium since 2002, when they won 2-1.
How to watch
The game kicks off at 15:00 GMT on Saturday March 12.
It is not available to watch in the UK but overseas supporters can purchase a live stream of the game via either club website.