Having gone unbeaten in their final 12 matches of the season, the Chairboys finished sixth in the table, carrying momentum with them ahead of this tie.
Lewis Wing returned to the side last week, but it's expected that Dominic Gape will retain his place in the midfield.
Jack Young looks to be out while midfield duo of Brandon Hanlan and Anis Mehmeti are considered doubtful.
Mohamed Eisa is the only player that may not feature as the forward could miss his fourth game on the spin with a right ankle injury.
Wycombe Wanderers: Stockdale; Jacobson, Tafazolli, Stewart, McCarthy; Scowen, Gape; Obita, Horgan, McCleary; Vokes
Milton Keynes Dons: Cumming; Lewington, Darling, O'Hora; Harvie, McEachran, Kasumu, Coventry, Hayden; Parrott, Twine
Ones to watch
David Stockdale (Wycombe Wanderers)
The Chairboys goalkeeper paced League One with 18 clean sheets and is a big reason why his side have not conceded a goal in their last six matches at home.
Scott Twine (Milton Keynes Dons)
The Dons top scorer found the back of the net four times against Plymouth, bringing his total to 20 for the season and he scored the winner the last time this fixture was played.
He ranked fifth in League One in goals and second in assists with 13, making him one of the most dangerous attacking players in the third tier.
MK Dons won both league matches against Wycombe by a single goal with Troy Parrott netting a 40th-minute penalty in the first matchup at home in September and Twine scoring in the 13th minute in late January.
In the Football League Trophy, the Dons were 2-1 winners as Zak Jules potted the winner after first-half goals by Hiram Boateng and Hanlan did nothing to separate the sides.
The match will be televised on Sky Sports Football with coverage beginning at 19:00 BST. Kick-off is set for 19:45.